Garg Pooja, Ghalaut Pankaj, Dahiya Kiran, Ravi Reena, Sharma Anshu, Wakure Poonam
Department of Prosthodontics, Post Graduate Institute of Medical Sciences, Pt. B.D Sharma University of Health Sciences, Rohtak, Haryana, India.
Department of Biochemistry, Post Graduate Institute of Medical Sciences, Pt. B.D Sharma University of Health Sciences, Rohtak, Haryana, India.
Natl J Maxillofac Surg. 2020 Jul-Dec;11(2):199-206. doi: 10.4103/njms.NJMS_49_20. Epub 2020 Dec 16.
Vitamin D has been shown to play a vital role in bone mineral homeostasis by stimulating the intestinal absorption of calcium and phosphate. The critical role of Vitamin D in bone metabolism triggered the need to evaluate the effect of Vitamin D deficiency and hence replacement of the same on osseointegration of dental implants. This prospective study evaluated the crestal bone level in patients having low level of Vitamin D treated with dental implant with or without Vitamin D3 supplements.
A prospective clinical study was conducted on 32 patients based on the inclusion and exclusion criteria. Patients were divided into two groups on the basis of Vitamin D level < 30 ng/ml (Group I: patients receiving Vitamin D3 supplements, i.e., cholecalciferol 1 g sachet 60,000 IU/month) or <30 ng/ml (Group II: not receiving Vitamin D3 supplements). The crestal bone level measurements were made with the help of Digimizer Image Analysis, MedCalc software.
All implants showed clinically acceptable crestal bone level at interval of 1 week (baseline), 3 months, and 6 months. There was a statistically nonsignificant difference seen for the values between the groups ( > 0.05) for all other values at various time intervals. However, there was a statistically significant/highly significant difference seen for the values between the groups ( < 0.01, 0.05) for 3 months distal with higher values for Group I as compared to Group II.
From the study, it can be concluded that cholecalciferol has systemic effects on accelerating bone formation around titanium implant.
维生素D已被证明通过刺激肠道对钙和磷的吸收，在骨矿物质稳态中发挥至关重要的作用。维生素D在骨代谢中的关键作用引发了评估维生素D缺乏的影响以及补充维生素D对牙种植体骨整合影响的需求。这项前瞻性研究评估了接受或未接受维生素D3补充剂治疗的维生素D水平低的患者种植体周围嵴顶骨水平。
根据纳入和排除标准，对32例患者进行了一项前瞻性临床研究。根据维生素D水平<30 ng/ml将患者分为两组（第一组：接受维生素D3补充剂，即胆钙化醇1 g小袋，60,000 IU/月）或<30 ng/ml（第二组：未接受维生素D3补充剂）。借助Digimizer图像分析软件MedCalc进行嵴顶骨水平测量。
所有种植体在1周（基线）、3个月和6个月时均显示出临床上可接受的嵴顶骨水平。在各个时间间隔的所有其他值中，两组之间的值存在统计学上无显著差异（>0.05）。然而，在3个月时，两组之间的值存在统计学上的显著/高度显著差异（<0.01, 0.05），第一组的值高于第二组。
从研究中可以得出结论，胆钙化醇对加速钛种植体周围的骨形成具有全身作用。
