Glushkov Andrew, Polenok Elena, Gordeeva Lyudmila, Mun Stella, Kostyanko Mikhail, Antonov Alexandr, Verzhbitskaya Natalia, Vafin Ilgiz
Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, Kemerovo, Russia.
Department of Organic and Physical Chemistry, Institute of Fundamental Sciences, Kemerovo State University, Kemerovo, Russia.
Cent Eur J Immunol. 2021;46(1):68-75. doi: 10.5114/ceji.2021.104462. Epub 2021 Mar 18.
Antibodies to estradiol and progesterone (Es and Pg) modulated their blood serum concentration and biological effects in immunized animals. Antibodies to membrane steroid receptors acted as hormone agonists or antagonists in cell cultures.
Here we studied the levels of Es and Pg, idiotypic immunoglobulin (Ig) A1 and anti-idiotypic IgG2 specific to Es and Pg in the serum of postmenopausal women (82 healthy donors and 443 breast cancer patients).
It was found that individual high ratios of Pg/Es (> 4), IgA-Pg1/IgA-Es1 (> 1) and IgG-Pg2/IgG-Es2 (> 1) were associated with low breast cancer risk (OR = 0.4-0.5). High ratios of IgA-Pg1/IgA-Es1 and IgG-Pg2/IgG-Es2 were associated with a high Pg/Es ratio in healthy women but not in breast cancer patients. The levels of idiotypic IgA to benzo[a]pyrene correlated significantly with IgA-Es1 and IgA-Pg1 levels in both compared groups. IgA-Pg1/IgA-Es1 ratio correlated with IgG-Pg2/IgG-Es2 only in healthy women but not in breast cancer patients.
The normal immune-hormonal balance supports the real adaptation of the organism to environmental carcinogens and inhibits the initiation and promotion of carcinogenesis. The disturbance between certain elements of this network (immune-hormonal disbalance) could stimulate carcinogenesis. Further studies of immune-hormonal interaction could be helpful for understanding the pathogenesis of other carcinogen-induced steroid-dependent diseases in humans.
抗雌二醇和孕酮（E和P）抗体可调节其在免疫动物体内的血清浓度及生物学效应。膜类固醇受体抗体在细胞培养中可作为激素激动剂或拮抗剂。
我们研究了绝经后女性（82名健康供体和443名乳腺癌患者）血清中E和P、E和P特异性独特型免疫球蛋白（Ig）A1及抗独特型IgG2的水平。
发现个体的P/E（>4）、IgA-P1/IgA-E1（>1）和IgG-P2/IgG-E2（>1）比值较高与较低的乳腺癌风险相关（比值比=0.4-0.5）。IgA-P1/IgA-E1和IgG-P2/IgG-E2比值较高在健康女性中与较高的P/E比值相关，但在乳腺癌患者中并非如此。在两个比较组中，苯并[a]芘独特型IgA水平与IgA-E1和IgA-P1水平显著相关。仅在健康女性中，IgA-P1/IgA-E1比值与IgG-P2/IgG-E2相关，而在乳腺癌患者中并非如此。
正常的免疫-激素平衡支持机体对环境致癌物的实际适应，并抑制致癌作用的起始和促进。该网络某些要素之间的紊乱（免疫-激素失衡）可能刺激致癌作用。进一步研究免疫-激素相互作用可能有助于理解人类其他致癌物诱导的类固醇依赖性疾病的发病机制。
