Ferris Craig F
Department Psychology and Pharmaceutical Sciences, Center for Translational Neuroimaging, Northeastern University, Boston, MA, United States.
Front Neurosci. 2021 Apr 8;15:624690. doi: 10.3389/fnins.2021.624690. eCollection 2021.
Critical studies that form the foundation of the glymphatic system and the clearance of metabolic by-products of unwanted proteins from the brain are reviewed. Concerns are raised about studying glymphatic flow in anesthetized animals and making assumptions about the whole brain based upon data collected from a cranial window on the cortex. A new model is proposed arguing that the flow of cerebral spinal fluid and parenchymal clearance in the perivascular system of unwanted proteins is regulated by circadian changes in brain temperature and blood flow at the level of the microvasculature.
本文综述了构成类淋巴系统基础以及大脑中不需要蛋白质代谢副产物清除机制的关键研究。文中对在麻醉动物身上研究类淋巴流动以及基于从皮质颅窗收集的数据对整个大脑进行假设提出了担忧。提出了一种新模型，认为脑脊髓液的流动以及血管周围系统中不需要蛋白质的实质清除是由微血管水平上脑温度和血流的昼夜变化所调节的。
