• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在不存在门静脉高压的情况下，犬门体分流中的血管活性肠肽。

Vasoactive intestinal peptide in canine portosystemic shunt in the absence of portal hypertension.

机构信息

Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.

出版信息

Open Vet J. 2021 Jan-Mar;11(1):39-41. doi: 10.4314/ovj.v11i1.7. Epub 2021 Jan 20.

DOI:10.4314/ovj.v11i1.7
PMID:33898282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8057220/
Abstract

BACKGROUND

The congenital portosystemic shunt (PSS) is a common vascular anomaly in dogs. Vasoactive intestinal peptide (VIP) is produced in various organs (including the small intestine, large intestine, and pancreas), leading to abdominal vasodilation, increased blood flow, increased pancreatic blood flow, and promotion of pancreatic endocrine and exocrine secretions. However, there have been no reports on the concentration of VIP in the portal and peripheral veins in canine PSS.

AIM

The aim of this pilot study was to evaluate whether dogs with PSS have a different VIP concentration in their portal system in general.

METHODS

Six dogs with an extrahepatic portosplenic shunt were included in the study. Blood samples were taken from the saphenous and portal veins during PSS ligation surgery with an amerid constrictor, to evaluate and compare the VIP concentration in both samples. VIP was measured using a commercial canine enzyme-linked immunosorbent assay kit.

RESULTS

The breeds included Mongrels ( = 2), Norfolk Terriers ( = 1), Miniature Dachshunds ( = 1), and Maltese ( = 2), and their ages were 9.3 ± 6.5 months; the bodyweight was 3.3 ± 0.8 kg. The concentration of VIP in the saphenous vein was 17.75 ± 13.88 pg/ml; on the contrary, the concentration of VIP in the portal vein was 29.7 ± 20.29 pg/ml. There was no significant difference in the VIP concentration between veins.

CONCLUSION

There was no difference in the VIP concentration between the portal and saphenous veins, suggesting a non-association between VIP and the PSS, in the absence of portal hypertension.

摘要

背景

先天性门体分流（PSS）是犬的一种常见血管异常。血管活性肠肽（VIP）在各种器官（包括小肠、大肠和胰腺）中产生，导致腹部血管扩张、血流量增加、胰腺血流量增加，并促进胰腺内分泌和外分泌分泌。然而，目前还没有关于犬 PSS 门静脉和外周静脉中 VIP 浓度的报道。

目的

本初步研究旨在评估 PSS 犬的门静脉系统中 VIP 浓度是否存在差异。

方法

本研究纳入了 6 只患有肝外门体分流的犬。在使用 amerid 缩窄器结扎 PSS 手术期间，从隐静脉和门静脉采集血样，以评估和比较两种样本中的 VIP 浓度。使用商业犬酶联免疫吸附测定试剂盒测量 VIP。

结果

包括杂种犬（=2）、诺福克梗犬（=1）、迷你杜宾犬（=1）和马尔济斯犬（=2），年龄为 9.3±6.5 个月，体重为 3.3±0.8kg。隐静脉中 VIP 的浓度为 17.75±13.88pg/ml；相反，门静脉中 VIP 的浓度为 29.7±20.29pg/ml。静脉中 VIP 浓度无显著差异。

结论

在没有门静脉高压的情况下，门静脉和隐静脉之间 VIP 浓度没有差异，表明 VIP 与 PSS 之间没有关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a510/8057220/f53b778826ab/OpenVetJ-11-39-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a510/8057220/f53b778826ab/OpenVetJ-11-39-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a510/8057220/f53b778826ab/OpenVetJ-11-39-g001.jpg

相似文献

1
Vasoactive intestinal peptide in canine portosystemic shunt in the absence of portal hypertension.在不存在门静脉高压的情况下，犬门体分流中的血管活性肠肽。
Open Vet J. 2021 Jan-Mar;11(1):39-41. doi: 10.4314/ovj.v11i1.7. Epub 2021 Jan 20.
2
Hepatic inactivation of vasoactive intestinal peptide in man and dog.人及犬体内血管活性肠肽的肝脏失活作用。
Ann Surg. 1978 Jul;188(1):28-33. doi: 10.1097/00000658-197807000-00004.
3
Liver size, bodyweight, and tolerance to acute complete occlusion of congenital extrahepatic portosystemic shunts in dogs.犬先天性肝外门体分流急性完全闭塞时的肝脏大小、体重及耐受性
Vet Surg. 2008 Oct;37(7):656-62. doi: 10.1111/j.1532-950X.2008.00432.x.
4
Effect of breed on anatomy of portosystemic shunts resulting from congenital diseases in dogs and cats: a review of 242 cases.品种对犬猫先天性疾病所致门体分流解剖结构的影响：242例病例回顾
Aust Vet J. 2004 Dec;82(12):746-9. doi: 10.1111/j.1751-0813.2004.tb13233.x.
5
Contrast-enhanced ultrasonography is a feasible technique for quantifying hepatic microvascular perfusion in dogs with extrahepatic congenital portosystemic shunts.超声造影是一种用于量化患有肝外先天性门体分流的犬肝脏微血管灌注的可行技术。
Vet Radiol Ultrasound. 2019 Mar;60(2):192-200. doi: 10.1111/vru.12699. Epub 2018 Dec 9.
6
Ultrasonographic evaluation of partially attenuated congenital extrahepatic portosystemic shunts in 14 dogs.14只犬部分性先天性肝外门体分流的超声评估
Vet Rec. 2004 Oct 9;155(15):448-56. doi: 10.1136/vr.155.15.448.
7
Ultrasonographic assessment of hemodynamic changes in the portal vein during surgical attenuation of congenital extrahepatic portosystemic shunts in dogs.犬先天性肝外门体分流手术减流过程中门静脉血流动力学变化的超声评估
J Am Vet Med Assoc. 2004 Feb 1;224(3):395-402. doi: 10.2460/javma.2004.224.395.
8
Ultrasonographic diagnosis of portosystemic shunting in dogs and cats.犬猫门体分流的超声诊断
Vet Radiol Ultrasound. 2004 Sep-Oct;45(5):424-37. doi: 10.1111/j.1740-8261.2004.04076.x.
9
Congenital portosystemic shunts in Maltese and Australian cattle dogs.马尔济斯犬和澳大利亚牧牛犬的先天性门体分流。
Aust Vet J. 1994 Jun;71(6):174-8. doi: 10.1111/j.1751-0813.1994.tb03382.x.
10
Use of transcolonic portal scintigraphy to evaluate efficacy of cellophane banding of congenital extrahepatic portosystemic shunts in 16 dogs.采用经结肠门静脉闪烁显像术评估16只犬先天性肝外门体分流术透明膜带环扎术的疗效。
Aust Vet J. 2008 May;86(5):169-79; quiz CE1. doi: 10.1111/j.1751-0813.2008.00278.x.

本文引用的文献

1
Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts.先天性门体分流犬的脂多糖和Toll样受体4
Vet J. 2015 Dec;206(3):404-13. doi: 10.1016/j.tvjl.2015.07.006. Epub 2015 Jul 7.
2
Attenuation of congenital portosystemic shunt reduces inflammation in dogs.先天性门体分流的减轻可减轻犬类的炎症。
PLoS One. 2015 Feb 6;10(2):e0117557. doi: 10.1371/journal.pone.0117557. eCollection 2015.
3
Plasma cytokine concentrations in dogs with a congenital portosystemic shunt.患有先天性门体分流的犬的血浆细胞因子浓度。
Vet J. 2014 Apr;200(1):197-9. doi: 10.1016/j.tvjl.2014.01.007. Epub 2014 Jan 17.
4
High-frequency vagus nerve stimulation improves portal hypertension in cirrhotic rats.高频迷走神经刺激可改善肝硬化大鼠的门静脉高压。
Gut. 2012 Apr;61(4):604-12. doi: 10.1136/gutjnl-2011-301396. Epub 2011 Dec 20.
5
The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair.肝微循环：肝损伤与修复中的机制作用及治疗靶点
Physiol Rev. 2009 Oct;89(4):1269-339. doi: 10.1152/physrev.00027.2008.
6
The distribution of nerve fibres immunoreactive for vasoactive intestinal peptide, calcitonin gene-related peptide, substance P and dopamine beta-hydroxylase in the normal equine larynx.正常马喉中对血管活性肠肽、降钙素基因相关肽、P物质和多巴胺β-羟化酶免疫反应阳性的神经纤维分布
Res Vet Sci. 1999 Dec;67(3):251-9. doi: 10.1053/rvsc.1999.0325.
7
Effects of portal vein stenosis and superior mesenteric vein ligation on mesenteric venous pressure and porta-systemic shunting in the rat.门静脉狭窄和肠系膜上静脉结扎对大鼠肠系膜静脉压力及门体分流的影响。
J Invest Surg. 1994 Nov-Dec;7(6):477-83. doi: 10.3109/08941939409015364.
8
Role of vasoactive intestinal polypeptide (VIP) in the neurogenic vasodilatation of the portal vein in the rabbit.血管活性肠肽（VIP）在兔门静脉神经源性血管舒张中的作用。
Regul Pept. 1985 Nov 28;12(4):309-16. doi: 10.1016/0167-0115(85)90174-0.
9
Corelease of PHI and VIP by vagal stimulation in the dog.犬迷走神经刺激引起的PHI和VIP共同释放
Am J Physiol. 1987 Jul;253(1 Pt 1):G13-9. doi: 10.1152/ajpgi.1987.253.1.G13.
10
Nervous release of vasoactive intestinal polypeptide in the gastrointestinal tract of cats: possible physiological implications.猫胃肠道中血管活性肠肽的神经释放：可能的生理意义。
J Physiol. 1978 Nov;284:291-305. doi: 10.1113/jphysiol.1978.sp012541.