Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.
School of Veterinary Medicine and Science, College Road, Sutton Bonington, University of Nottingham, Nottingham, UK.
Open Vet J. 2021 Jan-Mar;11(1):128-134. doi: 10.4314/ovj.v11i1.19. Epub 2021 Feb 16.
One of the major problems observed in veterinary practice is articular cartilage injuries in animals. In terms of agriculture, it leads to their culling from the herd, even if they are highly productive animals. With companion animals, owners usually have to decide between euthanasia or long-term sometimes lifelong treatment of the injury by a veterinarian. The use of mesenchymal stem cells (MSCs) for the treatment of cartilage injury in veterinary medicine is based on the good results observed in preclinical studies, where large animals have been used as experimental models to study the regenerative activity of MSCs. According to the literature, MSCs in veterinary medicine have been used to treat cartilage injury of dogs and horses, whereas sheep and goats are generally models for reproducing the disease in preclinical experimental studies.
兽医实践中观察到的主要问题之一是动物的关节软骨损伤。就农业而言，即使这些动物具有很高的生产力，它们也会被从畜群中淘汰。对于伴侣动物，主人通常必须在安乐死或由兽医进行长期（有时是终身）治疗之间做出选择。间充质干细胞（MSCs）在兽医医学中用于治疗软骨损伤是基于在临床前研究中观察到的良好结果，在这些研究中，大型动物被用作实验模型来研究 MSCs 的再生活性。根据文献，间充质干细胞已被用于治疗狗和马的软骨损伤，而绵羊和山羊通常是用于在临床前实验研究中复制该疾病的模型。
