Oslo Sports Trauma Research Center, Norwegian School of Sports Sciences, PO Box 4014, Ullevaal Stadion, 0806 Oslo, Norway.
Knee Surg Sports Traumatol Arthrosc. 2009 Nov;17(11):1289-97. doi: 10.1007/s00167-009-0782-4. Epub 2009 Mar 31.
Articular cartilage injury remains one of the major concerns in orthopaedic surgery. Mesenchymal stem cell (MSC) transplantation has been introduced to avoid some of the side effects and complications of current techniques. The purpose of this paper is to review the literature on MSC-based cell therapy for articular cartilage repair to determine if it can be an alternative treatment for cartilage injury. MSCs retain both high proliferative potential and multipotentiality, including chondrogenic differentiation potential, and a number of successful results in transplantation of MSCs into cartilage defects have been reported in animal studies. However, the use of MSCs for cartilage repair is still at the stage of preclinical and phase I studies, and no comparative clinical studies have been reported. Therefore, it is difficult to make conclusions in human studies. This requires randomized clinical trials to evaluate the effectiveness of MSC-based cell therapy for cartilage repair.
关节软骨损伤仍然是矫形外科的主要关注点之一。间充质干细胞（MSC）移植的引入是为了避免当前技术的一些副作用和并发症。本文旨在综述基于 MSC 的细胞治疗关节软骨修复的文献，以确定其是否可作为软骨损伤的替代治疗方法。MSC 具有高增殖潜能和多能性，包括成软骨分化潜能，并且在动物研究中已经报道了将 MSC 移植到软骨缺损中获得了许多成功的结果。然而，MSC 用于软骨修复仍处于临床前和 I 期研究阶段，尚未报道比较性临床研究。因此，在人类研究中难以得出结论。这需要进行随机临床试验来评估基于 MSC 的细胞治疗软骨修复的效果。
