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印度尼西亚雅加达一家二级医院中 COVID-19 的临床、实验室检查结果与胸部 CT 之间的关联

Association between clinical, laboratory findings and chest CT in COVID-19 in a secondary hospital in Jakarta, Indonesia.

作者信息

Hafiz Muhammad, Icksan Aziza Ghanie, Harlivasari Annisa Dian, Andarini Sita, Susanti Febrina, Yuliana Merryl Esther

机构信息

MD, Department of Pulmonology, Budhi Asih Teaching Hospital, Universitas Trisakti, Dewi Sartika street 13630, East Jakarta, Indonesia.

PhD, Department of Radiology, Persahabatan Hospital, Universitas Pembangunan Nasional, Dewi Sartika street 13630, East Jakarta, Indonesia.

出版信息

Germs. 2021 Mar 15;11(1):32-38. doi: 10.18683/germs.2021.1238. eCollection 2021 Mar.

Abstract

INTRODUCTION

A new emerging infectious disease caused by SARS-CoV-2 has caused a global pandemic. Early diagnosis is essential to prevent and halt the spread of the disease, patient management and isolation. In this study, we aimed to reveal correlations between clinical and laboratory findings with chest CT.

METHODS

This in an observational case series single center study in a secondary hospital in Jakarta, Indonesia. Patients were included if they had typical symptoms and positive RT-PCR for SARS-CoV-2.

RESULTS

Forty-two patients with positive RT-PCR were included in this study. Typical CT findings were present in 33 (78.6%). We found a positive correlation between patients in whom the imaging was performed after the 4 day of symptoms and chest CT findings (r=0.365 p<0.05). In receiver operating characteristic analysis of this parameter, the area under curve (AUC) was 0.678, and the sensitivity and specificity were 0.96 and 0.44, respectively.

CONCLUSIONS

Early diagnosis of COVID-19 is essential to promptly isolate and treat suspected patients. Utilization of chest CT to help diagnosis in this pandemic era needs to be considered by healthcare facilities especially if RT-PCR is limited.

摘要

引言

由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的一种新出现的传染病已导致全球大流行。早期诊断对于预防和阻止疾病传播、患者管理及隔离至关重要。在本研究中,我们旨在揭示临床和实验室检查结果与胸部CT之间的相关性。

方法

这是在印度尼西亚雅加达一家二级医院进行的一项观察性病例系列单中心研究。如果患者有典型症状且严重急性呼吸综合征冠状病毒2逆转录聚合酶链反应(RT-PCR)呈阳性,则纳入研究。

结果

本研究纳入了42例RT-PCR呈阳性的患者。33例(78.6%)出现典型的CT表现。我们发现症状出现4天后进行影像学检查的患者与胸部CT表现之间存在正相关(r=0.365,p<0.05)。在该参数的受试者工作特征分析中,曲线下面积(AUC)为0.678,敏感性和特异性分别为0.96和0.44。

结论

2019冠状病毒病(COVID-19)的早期诊断对于及时隔离和治疗疑似患者至关重要。在这个大流行时代,医疗设施需要考虑利用胸部CT来辅助诊断,特别是在RT-PCR检测受限的情况下。

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