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具有扩散、时滞和非线性发生率的海洛因模型的稳定性与分支分析

Stability and bifurcation analysis of a heroin model with diffusion, delay and nonlinear incidence rate.

作者信息

Kundu Soumen, Kumari Nitu, Kouachi Said, Kundu Piu

机构信息

Department of Mathematics, ICFAI Science School, Faculty of Science and Technology, ICFAI University Tripura, Agartala, Tripura 799210 India.

School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, Himachal Pradesh 175005 India.

出版信息

Model Earth Syst Environ. 2022;8(1):1351-1362. doi: 10.1007/s40808-021-01164-x. Epub 2021 Apr 20.

Abstract

As we all know, the use of heroin and other drugs in Europe and more specifically in Ireland and the resulting prevalence are well documented. A huge population is still dying using heroin every day. This may happen due to, several reasons like, excessive use of painkiller, lack of awareness etc. It has also inspired mathematical modelers to develop dynamical systems predicting the use of heroin in long run. In this work, the effect of heroin in Europe has been discussed by constructing a suitable mathematical model. Our model describes the process of treatment for heroin users by consolidating a sensible utilitarian structure that speaking to the restricted accessibility of treatment. In the treatment time frame, because of the discretion of the medication clients, some kind of time delay called immunity delay might be found. The effect of immunity delay on the system's stability has been examined. The existence of positive solution and its boundedness has been established. Also, the local stability of the interior equilibrium point has been studied. Taking the immunity delay as the key parameter, the condition for Hopf-bifurcation has been studied. Using normal form theory and center manifold theorem, we have likewise talked about the direction and stability of delay induced Hopf-bifurcation. The corresponding reaction diffusion system with Dirichlet boundary condition has been considered and the Turing instability has been studied. Obtained solutions have also been plotted by choosing a suitable value of the parameters as the support of our obtained analytical results.

摘要

众所周知,欧洲,尤其是爱尔兰使用海洛因及其他毒品的情况以及由此产生的流行率都有详尽记录。每天仍有大量人口死于海洛因使用。这可能是由于多种原因造成的,比如过度使用止痛药、意识缺乏等。这也促使数学建模者开发动态系统以长期预测海洛因的使用情况。在这项工作中,通过构建一个合适的数学模型来讨论海洛因在欧洲的影响。我们的模型通过整合一个合理的功利主义结构来描述海洛因使用者的治疗过程,该结构反映了治疗资源的有限可及性。在治疗时间段内,由于药物使用者的自行决定,可能会发现一种称为免疫延迟的时间延迟。研究了免疫延迟对系统稳定性的影响。确立了正解的存在性及其有界性。此外,研究了内部平衡点的局部稳定性。以免疫延迟作为关键参数,研究了霍普夫分岔的条件。利用范式理论和中心流形定理,我们还讨论了延迟诱导霍普夫分岔的方向和稳定性。考虑了具有狄利克雷边界条件的相应反应扩散系统,并研究了图灵不稳定性。通过选择合适的参数值绘制了得到的解,以支持我们获得的分析结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44d9/8055444/cefc590730f0/40808_2021_1164_Fig1_HTML.jpg

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