甲基汞和锰诱导的神经毒性潜在机制的新见解。
New insights on mechanisms underlying methylmercury-induced and manganese-induced neurotoxicity.
作者信息
Martins Airton C, Ke Tao, Bowman Aaron B, Aschner Michael
机构信息
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.
School of Health Sciences, Purdue University, West Lafayette, IN, USA.
出版信息
Curr Opin Toxicol. 2021 Mar;25:30-35. doi: 10.1016/j.cotox.2021.03.002. Epub 2021 Mar 15.
Abstract
Toxic and essential elements are widely distributed in the Earth's crust and individuals may be exposed to several of them. Indeed, exposure to toxic elements such as mercury (Hg) can be a potential health risk factor of health, mainly by ingestion of fish containing methylmercury (MeHg). On the other hand, essential elements such as manganese (Mn) play an important role in physiological process in human body. However, Mn overexposure may cause toxic effects. In this respect, the neurotoxic effects of MeHg and Mn on the developing brain are well recognized. Therefore, in this critical review, we address the effects of MeHg and Mn on cell signaling pathways which may contribute to molecular mechanisms involved in MeHg- and Mn-induced neurotoxicity.
摘要
有毒元素和必需元素广泛分布于地壳中，个体可能会接触到其中的多种元素。事实上，接触汞（Hg）等有毒元素可能是一种潜在的健康风险因素，主要通过摄入含有甲基汞（MeHg）的鱼类。另一方面，锰（Mn）等必需元素在人体生理过程中发挥着重要作用。然而，锰的过度暴露可能会导致毒性作用。在这方面，甲基汞和锰对发育中大脑的神经毒性作用已得到充分认识。因此，在这篇批判性综述中，我们探讨了甲基汞和锰对细胞信号通路的影响，这些影响可能有助于阐明甲基汞和锰诱导神经毒性的分子机制。
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