可溶性白细胞介素-6 受体在 COVID-19 细胞因子风暴综合征中的作用。
Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome.
机构信息
Division of Hematology, University of British Columbia, Vancouver, BC V5Z1M9, Canada.
Centre for Health Education Scholarship, University of British Columbia, Vancouver, BC V6T1Z3, Canada.
出版信息
Cell Rep Med. 2021 May 18;2(5):100269. doi: 10.1016/j.xcrm.2021.100269. Epub 2021 Apr 19.
Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 -signaling and how understanding the IL-6:sIL-6R axis might help define and treat COVID-19 cytokine storm syndrome.
数据表明，白细胞介素 (IL)-6 阻断可能降低重症 COVID-19 的死亡率，但大多数患者的 IL-6 水平仅略有升高。Chen 等人描述了可溶性白细胞介素-6 受体 (sIL-6R) 在 IL-6 信号传导中的作用，以及了解 IL-6:sIL-6R 轴如何帮助定义和治疗 COVID-19 细胞因子风暴综合征。
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