活动性类风湿关节炎患者（无论有无缺铁）铁吸收减少。
Decreased iron absorption in patients with active rheumatoid arthritis, with and without iron deficiency.
作者信息
Weber J, Werre J M, Julius H W, Marx J J
机构信息
Department of Rheumatology, Hospital de Malberg GZ, Arnhem, The Netherlands.
出版信息
Ann Rheum Dis. 1988 May;47(5):404-9. doi: 10.1136/ard.47.5.404.
Abstract
Mucosal uptake, mucosal transfer, and retention of a physiological dose of ferrous iron were studied in women with active rheumatoid arthritis (RA): 19 with normal and 17 with depleted bone marrow iron stores. Control subjects were 26 normal women and 20 women with uncomplicated iron deficiency. Iron absorption was measured with 59Fe as a tracer and by whole body counting. Compared with controls, final iron retention was considerably decreased in both groups of patients with RA. Analysis of the two sequential steps of iron absorption showed that mucosal uptake was normal in iron replete patients with RA but was significantly lower in patients with RA with depleted iron stores compared with iron deficient controls. Mucosal transfer of iron was considerably decreased in patients with RA with normal iron stores. The impaired absorption of iron in patients with active RA may delay the correction of the haemoglobin concentration when anaemia of chronic disease is complicated by iron deficiency.
摘要
在患有活动性类风湿关节炎（RA）的女性中研究了生理剂量的亚铁的黏膜摄取、黏膜转运和潴留情况：19名骨髓铁储存正常，17名骨髓铁储存耗尽。对照受试者为26名正常女性和20名无并发症的缺铁女性。用59Fe作为示踪剂并通过全身计数来测量铁吸收。与对照组相比，两组RA患者的最终铁潴留均显著降低。对铁吸收的两个连续步骤的分析表明，铁储备充足的RA患者的黏膜摄取正常，但与缺铁对照组相比，铁储备耗尽的RA患者的黏膜摄取显著降低。铁储备正常的RA患者的铁黏膜转运显著降低。当慢性病贫血并发缺铁时，活动性RA患者铁吸收受损可能会延迟血红蛋白浓度的纠正。
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