活动性类风湿关节炎会影响肠道铁吸收吗？
Does active rheumatoid arthritis affect intestinal iron absorption?
作者信息
Benn H P, Drews J, Randzio G, Jensen J M, Löffler H
机构信息
Second Department of Internal Medicine, University of Kiel, FRG.
出版信息
Ann Rheum Dis. 1988 Feb;47(2):144-9. doi: 10.1136/ard.47.2.144.
Abstract
One of the causes of anaemia in rheumatoid arthritis is thought to be defective iron absorption. In this study the 59Fe absorption in patients with active rheumatoid arthritis is measured and correlated with the results for bone marrow iron stores (and in some cases with the iron stores in the terminal duodenum), which were assessed simultaneously with semiquantitative methods, and with the serum ferritin concentration. In 11 patients with rheumatoid arthritis and increased bone marrow iron stores, iron absorption was decreased. In five patients it was normal and in three further patients, whose bone marrow iron stores were depleted, iron absorption was maximally increased. According to the results both intestinal malabsorption and defective iron absorption can be excluded as causes.
摘要
类风湿性关节炎贫血的原因之一被认为是铁吸收不良。在本研究中，对活动期类风湿性关节炎患者的⁵⁹铁吸收情况进行了测量，并与骨髓铁储存结果（在某些情况下还与十二指肠末端的铁储存）进行了关联，这些结果是通过半定量方法同时评估的，还与血清铁蛋白浓度进行了关联。在11例骨髓铁储存增加的类风湿性关节炎患者中，铁吸收减少。在5例患者中，铁吸收正常，在另外3例骨髓铁储存耗尽的患者中，铁吸收最大程度增加。根据这些结果，可以排除肠道吸收不良和铁吸收不良作为病因。
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