Emerg Infect Dis. 2021 May;27(5):1438-1445. doi: 10.3201/eid2705.204756.
Noroviruses are a leading cause of acute gastroenteritis (AGE) among adults and children worldwide. NoroSurv is a global network for norovirus strain surveillance among children <5 years of age with AGE. Participants in 16 countries across 6 continents used standardized protocols for dual typing (genotype and polymerase type) and uploaded 1,325 dual-typed sequences to the NoroSurv web portal during 2016-2020. More than 50% of submitted sequences were GII.4 Sydney[P16] or GII.4 Sydney[P31] strains. Other common strains included GII.2[P16], GII.3[P12], GII.6[P7], and GI.3[P3] viruses. In total, 22 genotypes and 36 dual types, including GII.3 and GII.20 viruses with rarely reported polymerase types, were detected, reflecting high strain diversity. Surveillance data captured in NoroSurv enables the monitoring of trends in norovirus strains associated childhood AGE throughout the world on a near real-time basis.
诺如病毒是导致全球成人和儿童急性肠胃炎（AGE）的主要原因。NoroSurv 是一个针对 5 岁以下患有 AGE 的儿童的诺如病毒株监测的全球性网络。来自六大洲 16 个国家的参与者使用了双重分型（基因型和聚合酶型）的标准化方案，并在 2016 年至 2020 年期间将 1325 个双重分型序列上传到 NoroSurv 门户网站。提交的序列中超过 50%是 GII.4 Sydney[P16]或 GII.4 Sydney[P31]株。其他常见的毒株包括 GII.2[P16]、GII.3[P12]、GII.6[P7]和 GI.3[P3]病毒。总共检测到 22 种基因型和 36 种双重类型，包括很少报道聚合酶类型的 GII.3 和 GII.20 病毒，反映了高毒株多样性。NoroSurv 中捕获的监测数据能够实时监测与全球儿童 AGE 相关的诺如病毒株的趋势。
