Starkstein S E, Robinson R G, Berthier M L, Parikh R M, Price T R
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
Arch Neurol. 1988 Jul;45(7):725-30. doi: 10.1001/archneur.1988.00520310031013.
Patients with computed tomographic scan-verified unilateral lesions in the basal ganglia or thalamus were examined for the presence of poststroke mood disorders. Patients with left-sided basal ganglia lesions (mainly in the head of the caudate nucleus) showed a significantly higher frequency and severity of depression, as compared with patients with right-sided basal ganglia or thalamic (left- or right-sided) lesions. Results suggest that damage to biogenic amine pathways and/or frontocaudate projections may play an important role in the modulation of mood.
对计算机断层扫描证实基底神经节或丘脑存在单侧病变的患者进行了中风后情绪障碍检查。与右侧基底神经节或丘脑（左侧或右侧）病变的患者相比，左侧基底神经节病变（主要在尾状核头部）的患者抑郁的发生率和严重程度明显更高。结果表明，生物胺途径和/或额尾状核投射受损可能在情绪调节中起重要作用。
