Cleveland Clinic, Cleveland, OH.
American Society of Clinical Oncology, Alexandria, VA.
J Clin Oncol. 2021 Jun 10;39(17):1909-1941. doi: 10.1200/JCO.21.00449. Epub 2021 Apr 26.
To provide evidence-based recommendations for practicing physicians and other healthcare providers on the management of salivary gland malignancy.
ASCO convened an Expert Panel of medical oncology, surgical oncology, radiation oncology, neuroradiology, pathology, and patient advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 2000 through 2020. Outcomes of interest included survival, diagnostic accuracy, disease recurrence, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations.
The literature search identified 293 relevant studies to inform the evidence base for this guideline. Six main clinical questions were addressed, which included subquestions on preoperative evaluations, surgical diagnostic and therapeutic procedures, appropriate radiotherapy techniques, the role of systemic therapy, and follow-up evaluations.
When possible, evidence-based recommendations were developed to address the diagnosis and appropriate preoperative evaluations for patients with a salivary gland malignancy, therapeutic procedures, and appropriate treatment options in various salivary gland histologies.Additional information is available at www.asco.org/head-neck-cancer-guidelines.
为临床医生和其他医疗保健提供者提供有关唾液腺癌管理的循证推荐意见。
美国临床肿瘤学会（ASCO）召集了肿瘤内科、肿瘤外科、放射肿瘤学、神经放射学、病理学和患者权益倡导专家组成专家小组，对 2000 年至 2020 年发表的系统评价、荟萃分析、随机对照试验和前瞻性及回顾性对照观察研究进行了文献检索。感兴趣的结局包括生存、诊断准确性、疾病复发和生活质量。专家小组成员利用现有证据和非正式共识制定了基于证据的指南推荐意见。
文献检索确定了 293 项相关研究，为该指南的循证基础提供了信息。共提出了 6 个主要临床问题，其中包括唾液腺癌患者术前评估、手术诊断和治疗程序、适当的放疗技术、全身治疗的作用以及随访评估等方面的亚问题。
当有可能时，制定了循证推荐意见，以解决唾液腺癌患者的诊断和适当的术前评估、治疗程序以及各种唾液腺组织学的适当治疗选择。更多信息可在 www.asco.org/head-neck-cancer-guidelines 上获取。
