建筑行业工人肺癌发病率和死亡率的系统评价和荟萃分析方案。
Incidence of lung cancer and mortality among civil construction industry workers: A protocol for a systematic review and meta-analysis.
机构信息
Departamento de Civil y Ambiental, Universidad de la Costa, Barranquilla, Atlántico, Colombia.
Programa de Pós-graduação em Ciências Biológicas: Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.
出版信息
PLoS One. 2021 Apr 26;16(4):e0250377. doi: 10.1371/journal.pone.0250377. eCollection 2021.
BACKGROUND
The construction sector is one of the most stable growth industries in the world. However, many studies have suggested an association between occupational exposure in civil construction and lung cancer risk. Thus, this study aims to assess lung cancer risk in civil construction workers occupationally exposed to physical and chemical agents through a systematic review and meta-analysis.
METHODS/DESIGN: Studies will be identified by searching PUBMED, Embase, SCOPUS, WEB OF SCIENCE and the reference list of included articles. Eligible study designs will be cohort, cross-sectional, and case-control studies that report occupational exposure to physical or chemical agents and lung cancer risk through mortality or incidence outcomes. A meta-analysis will be used to combine odds ratios (ORs) from case-control studies and relative risks (RR) from cohort studies. Two reviewers will independently screen articles, extract data, and assess scientific quality using standardized forms and ROBINS-E tool if available. Otherwise, the New-Castle Ottawa rating scale will be used. Any of those will also be used in combination with the GRADE approach for quality of evidence. Overall risk estimates and their corresponding 95% confidence intervals (CIs) will be obtained using the random-effects model meta-analysis. This systematic review and meta-analysis will be conducted following the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines. Results will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
DISCUSSION
This review will identify and synthesize studies investigating the association between occupational exposure in the construction industry and lung cancer. The findings will help governmental entities and researchers with evidence-based decision-making because they will integrate and validate the evidence on construction workers' health effects due to occupational exposure.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42020164209.
背景
建筑行业是世界上增长最稳定的行业之一。然而，许多研究表明，土木工程职业暴露与肺癌风险之间存在关联。因此，本研究旨在通过系统评价和荟萃分析评估职业暴露于物理和化学因素的土木工程工人的肺癌风险。
方法/设计：将通过搜索 PUBMED、Embase、SCOPUS、WEB OF SCIENCE 和纳入文章的参考文献来识别研究。合格的研究设计将是队列、横断面和病例对照研究，通过死亡率或发病率结果报告职业暴露于物理或化学因素与肺癌风险之间的关系。将使用荟萃分析合并病例对照研究的优势比 (OR) 和队列研究的相对风险 (RR)。两名审查员将独立筛选文章、使用标准化表格提取数据，并使用 ROBINS-E 工具（如果可用）或纽卡斯尔-渥太华量表评估科学质量。也将使用这些工具与 GRADE 方法相结合评估证据质量。使用随机效应模型荟萃分析获得总体风险估计值及其相应的 95%置信区间 (CI)。本系统评价和荟萃分析将遵循观察性研究荟萃分析的流行病学 (MOOSE) 指南进行。结果将根据系统评价和荟萃分析的首选报告项目 (PRISMA) 声明报告。
讨论
本综述将确定并综合研究职业暴露于建筑行业与肺癌之间的关联。研究结果将有助于政府实体和研究人员做出基于证据的决策，因为它们将整合和验证有关建筑工人因职业暴露而导致健康影响的证据。
系统评价注册
PROSPERO CRD42020164209。
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