Mione M C, Cavallotti C, Burnstock G, Amenta F
Department of Anatomy and Embryology, University College London.
Basic Appl Histochem. 1988;32(1):153-9.
The influence of pregnancy on the density and pattern of the peptidergic innervation of the guinea pig uterine artery was studied. Whole mount stretch preparations of the uterine artery from estrus and late pregnant guinea pigs were processed for the immunohistochemical demonstration of neuropeptide Y (NPY)-, vasoactive intestinal polypeptide (VIP)-, calcitonin gene-related peptide (CGRP)- and substance P (SP)- immunoreactive nerve fibres. In late pregnancy the density of NPY- and CGRP- containing nerve fibres was remarkably decreased, while that of VIP- and SP- immunoreactive nerves showed a moderate reduction. The meaning and the possible physiological relevance of the decreased density of peptide-immunoreactive nerves in the uterine artery in late pregnancy are discussed.
研究了妊娠对豚鼠子宫动脉肽能神经支配密度和模式的影响。对来自发情期和妊娠晚期豚鼠子宫动脉的整装拉伸标本进行处理，以免疫组织化学方法显示神经肽Y（NPY）、血管活性肠肽（VIP）、降钙素基因相关肽（CGRP）和P物质（SP）免疫反应性神经纤维。在妊娠晚期，含NPY和CGRP的神经纤维密度显著降低，而VIP和SP免疫反应性神经纤维密度则有中度降低。本文讨论了妊娠晚期子宫动脉中肽免疫反应性神经纤维密度降低的意义及其可能的生理相关性。
