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多种慢性疾病与背痛老年人身体机能和跌倒的关系:一项基于人群的纵向研究。

Associations of Multiple Chronic Conditions With Physical Performance and Falls Among Older Adults With Back Pain: A Longitudinal, Population-based Study.

机构信息

Department of Rehabilitation Medicine, University of Washington, Seattle, WA; Department of Health Services, University of Washington, Seattle, WA.

Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA; Sheltering Arms Institute, Richmond, VA.

出版信息

Arch Phys Med Rehabil. 2021 Sep;102(9):1708-1716. doi: 10.1016/j.apmr.2021.03.025. Epub 2021 Apr 24.

Abstract

OBJECTIVE

To determine the association of chronic conditions measured at baseline with physical performance and falls over time among older adults with back pain. We examined both number and type (depression, anxiety, arthritis) of chronic conditions.

DESIGN

Retrospective cohort study.

SETTING

National Health and Aging Trends Study.

PARTICIPANTS

A total of 2438 community-dwelling Medicare beneficiaries aged ≥65 years with bothersome back pain (N=2438). The sample was mostly female (62%; 95% confidence interval [CI], 59%-64%) and aged 65-74 years (56%; 95% CI, 53%-58%).

INTERVENTIONS

Not applicable.

MAIN OUTCOME MEASURES

Short Physical Performance Battery (SPPB) (range, 0-12, lower indicates worse function) and recurrent falls measured annually over 6 years.

RESULTS

Multiple chronic conditions were highly prevalent (82%; 95% CI, 79%-84%) among those reporting back pain. Adjusted regressions using survey weights with Taylor series linearization method and containing interaction terms for comorbidity and time showed having 2-3 chronic conditions vs 0-1 was associated with lower SPPB scores, and differences grew over time (for example 0.61 points lower [95% CI, -0.88 to -0.34] and 1.22 points lower [95% CI, -1.76 to -0.67] in rounds 3 and 6, respectively). Having ≥4 chronic conditions was associated with lower SPPB scores at all time points vs 0-1 (point estimate range, -1.72 to -2.31). Arthritis alone; the combination of arthritis with depression; and the triad of arthritis, depression, and anxiety were associated with lower SPPB scores at all time points. Logistic regression models showed presence of 2-3 and ≥4 chronic conditions was associated with increased odds of recurrent falls in any given year (odds ratio, 1.91; 95% CI, 1.35-2.69 and odds ratio, 3.92; 95% CI, 2.81-5.46, respectively). Those with the triad of arthritis, depression, and anxiety had greater odds of recurrent falls vs none or 1 condition.

CONCLUSIONS

Among older adults with back pain, those with multiple chronic conditions, including co-occurrence of arthritis, depression, and anxiety, have greater risk for poor physical functioning and falls over time.

摘要

目的

确定基线时测量的慢性疾病与老年人腰痛患者随时间推移的身体机能和跌倒之间的关联。我们研究了慢性疾病的数量和类型(抑郁、焦虑、关节炎)。

设计

回顾性队列研究。

地点

国家健康老龄化趋势研究。

参与者

共有 2438 名患有烦扰性腰痛(N=2438)且居住在社区的年满 65 岁的医疗保险受益人参试。该样本主要为女性(62%;95%置信区间[CI],59%-64%),年龄在 65-74 岁(56%;95% CI,53%-58%)。

干预措施

不适用。

主要观察指标

使用每年随访 6 年的简短身体表现电池(SPPB)(范围,0-12,分数越低表示功能越差)和复发性跌倒。

结果

报告腰痛的患者中,多种慢性疾病的患病率很高(82%;95% CI,79%-84%)。使用包含共病和时间交互项的具有泰勒级数线性化方法的调查权重调整回归显示,与 0-1 相比,患有 2-3 种慢性疾病与 SPPB 评分较低相关,且差异随时间增加(例如,第 3 轮和第 6 轮分别低 0.61 分[95% CI,-0.88 至 -0.34]和低 1.22 分[95% CI,-1.76 至 -0.67])。与 0-1 相比,患有≥4 种慢性疾病与所有时间点的 SPPB 评分较低相关(点估计范围,-1.72 至 -2.31)。仅关节炎;关节炎合并抑郁;以及关节炎、抑郁和焦虑三联征在所有时间点均与 SPPB 评分较低相关。逻辑回归模型显示,在任何给定年份,患有 2-3 种和≥4 种慢性疾病与复发性跌倒的几率增加相关(比值比,1.91;95% CI,1.35-2.69 和比值比,3.92;95% CI,2.81-5.46)。与无疾病或仅有一种疾病相比,患有关节炎、抑郁和焦虑三联征的患者复发性跌倒的几率更高。

结论

在患有腰痛的老年人中,患有多种慢性疾病(包括关节炎、抑郁和焦虑同时发生)的患者随时间推移,身体机能下降和跌倒的风险更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c454/8429055/3ce230bd5430/nihms-1696845-f0001.jpg

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