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COVID-19 患者的气管切开术:方案和结果。

Tracheotomies in COVID-19 Patients: Protocols and Outcomes.

机构信息

Professor and Kelly L. Krahwinkel Chairman, Department of Oral and Maxillofacial Surgery, University of Tennessee Graduate School of Medicine, Knoxville, TN.

Associate Professor of Biostatistics, Department of Surgery, University of Tennessee Graduate School of Medicine, Knoxville, TN.

出版信息

J Oral Maxillofac Surg. 2021 Aug;79(8):1629-1642. doi: 10.1016/j.joms.2021.03.004. Epub 2021 Mar 12.

Abstract

PURPOSE

Approximately 3-15% of COVID-19 patients will require prolonged mechanical ventilation thereby requiring consideration for tracheotomy. Guidelines for tracheotomy in this cohort of patients are therefore required with assessed outcomes of tracheotomies.

PATIENTS AND METHODS

A retrospective chart review was performed of COVID-19 patients undergoing tracheotomy. Inclusion criteria were the performance of a tracheotomy in COVID-19 positive patients between March 11 and December 31, 2020. Exclusion criteria were lack of consent, extubation prior to the performance of a tracheotomy, death prior to the performance of the tracheotomy, and COVID-19 patients undergoing tracheotomy who tested negative twice after medical treatment. The primary predictor variable was the performance of a tracheotomy in COVID-19 positive patients and the primary outcome variable was the time to cessation of mechanical ventilation with the institution of supplemental oxygen via trach mask.

RESULTS

Seventeen tracheotomies were performed between 4-25 days following intubation (mean = 17 days). Seven patients died between 4 and 16 days (mean = 8.7 days) following tracheotomy and 10 living patients realized cessation of mechanical ventilation from 4 hours to 61 days following tracheotomy (mean = 19.3 days). These patients underwent tracheotomy between 4 and 22 days following intubation (mean = 14 days). The 7 patients who died following tracheotomy underwent the procedure between 7 and 25 days following intubation (mean = 18.2 days). Seven patients underwent tracheotomy on or after 20 days of intubation and 3 survived (43%). Ten patients underwent tracheotomy before 20 days of intubation and 7 patients survived (70%). Significant differences between the mortality groups were detected for age (P = .006), and for P/F ratio at time of consult (P = .047) and the time of tracheotomy (P = .03).

CONCLUSIONS

Tracheotomies are safely performed in COVID-19 patients with a standardized protocol. The timing of tracheotomy in COVID-19 patients is based on ventilator parameters, P/F ratio, patient prognosis, patient advanced directives, and family wishes.

摘要

目的

大约 3-15%的 COVID-19 患者需要长时间接受机械通气,因此需要考虑进行气管切开术。因此,需要制定针对这一组患者的气管切开术指南,并评估气管切开术的结果。

患者和方法

对接受气管切开术的 COVID-19 患者进行回顾性病历审查。纳入标准为 2020 年 3 月 11 日至 12 月 31 日期间对 COVID-19 阳性患者进行气管切开术。排除标准为缺乏同意、在进行气管切开术之前拔管、在进行气管切开术之前死亡以及 COVID-19 患者在接受治疗后两次检测为阴性但仍进行气管切开术。主要预测变量为 COVID-19 阳性患者进行气管切开术,主要结局变量为开始机械通气至通过气管切开面罩给予补充氧气时停止机械通气的时间。

结果

在插管后 4-25 天(平均 17 天)进行了 17 例气管切开术。7 例患者在气管切开术后 4-16 天(平均 8.7 天)死亡,10 例存活患者在气管切开术后 4 小时至 61 天(平均 19.3 天)停止机械通气。这些患者在插管后 4-22 天(平均 14 天)进行气管切开术。气管切开术后死亡的 7 例患者在插管后 7-25 天(平均 18.2 天)进行了该手术。7 例患者在插管 20 天后进行气管切开术,其中 3 例存活(43%)。10 例患者在插管前 20 天进行气管切开术,其中 7 例存活(70%)。在死亡率组之间检测到年龄(P=0.006)、咨询时的 P/F 比(P=0.047)和气管切开术时间(P=0.03)存在显著差异。

结论

在 COVID-19 患者中使用标准化方案安全地进行气管切开术。COVID-19 患者的气管切开术时机取决于呼吸机参数、P/F 比、患者预后、患者的预先指示和家属的意愿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1740/7952266/188c2d506d02/gr1_lrg.jpg

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