School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, United Kingdom.
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, United Kingdom.
J Pharm Sci. 2021 Aug;110(8):2859-2872. doi: 10.1016/j.xphs.2021.04.012. Epub 2021 Apr 24.
The aim of this work was to identify from a review of current literature the effects of lipids used in the development of Nanostructured Lipid Carriers (NLCs) on the physicochemical properties of the resulting formulation. The size of the solid lipid, affected by the molecular weight and the complexity of the structure, tends to affect the particle size of the final formulation proportionally; the higher the molecular weight and the more complex the molecular structure, the bigger the particle size of the NLCs. However, there is no straight correlation between the size and the structure of the liquid lipid and the particle size. Moreover, there seems to be a correlation of the solid to liquid lipid ratio which affects the particle size; there has been a trend of increasing particle size when more solid lipid was used. Regarding the entrapment efficiency, it is highly affected by the drug and its interaction with the lipids, as its solubility in the lipids needs to be high so the drug can stay entrapped within the lipid core. There was no direct correlation between the type of lipid used or the ratio and the zeta potential, which affects the stability of the NLCs.
本工作旨在从现有文献综述中确定用于开发纳米结构脂质载体（NLC）的脂质对所得制剂理化性质的影响。固体脂质的大小受分子量和结构复杂性的影响，往往会成比例地影响最终制剂的粒径；分子量越高，分子结构越复杂，NLC 的粒径就越大。然而，液体脂质的大小和结构与粒径之间没有直接的相关性。此外，似乎存在一个与固液脂质比例相关的因素会影响粒径；当使用更多的固体脂质时，粒径有增大的趋势。至于包封效率，它受到药物及其与脂质的相互作用的高度影响，因为其在脂质中的溶解度需要高，以便药物能够留在脂质核内被包封。所使用的脂质的类型或比例与zeta 电位之间没有直接的相关性，zeta 电位会影响 NLC 的稳定性。
