Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.
Int J Nanomedicine. 2024 Aug 15;19:8091-8113. doi: 10.2147/IJN.S478964. eCollection 2024.
The current treatments for wound healing still exhibit drawbacks due to limited availability at the action sites, susceptibility to degradation, and immediate drug release, all of which are detrimental in chronic conditions. Nano-modification strategies, offering various advantages that can enhance the physicochemical properties of drugs, have been employed in efforts to maximize the efficacy of wound healing medications. Nowadays, nanostructured lipid carriers (NLCs) provide drug delivery capabilities that can safeguard active compounds from environmental influences and enable controlled release profiles. Consequently, NLCs are considered an alternative therapy to address the challenges encountered in wound treatment. This review delves into the application of NLCs in drug delivery for wound healing, encompassing discussions on their composition, preparation methods, and their impact on treatment effectiveness. The modification of drugs into the NLC model can be facilitated using relatively straightforward technologies such as pressure-based processes, emulsification techniques, solvent utilization methods, or phase inversion. Moreover, NLC production with minimal material compositions can accommodate both single and combination drug delivery. Through in vitro, in vivo, and clinical studies, it has been substantiated that NLCs can enhance the therapeutic potential of various drug types in wound healing treatments. NLCs enhance efficacy by reducing the active substance particle size, increasing solubility and bioavailability, and prolonging drug release, ensuring sustained dosage at the wound site for chronic wounds. In summary, NLCs represent an effective nanocarrier system for optimizing the bioavailability of active pharmacological ingredients in the context of wound healing.
当前的伤口愈合治疗方法仍然存在一些缺点，例如作用部位的可用性有限、易降解以及药物的即时释放，所有这些在慢性疾病中都是不利的。纳米修饰策略具有多种优势，可以增强药物的物理化学性质，因此被用于最大限度地提高伤口愈合药物的疗效。如今，纳米结构脂质载体（NLC）提供了药物输送能力，可以保护活性化合物免受环境影响，并实现控制释放特性。因此，NLC 被认为是一种替代疗法，可以解决伤口治疗中遇到的挑战。本综述深入探讨了 NLC 在药物输送中的应用，用于伤口愈合治疗，包括对其组成、制备方法以及对治疗效果的影响的讨论。可以使用相对简单的技术将药物修饰为 NLC 模型，例如基于压力的工艺、乳化技术、溶剂利用方法或相转变。此外，使用最少的材料组成生产 NLC 可以适应单一和组合药物输送。通过体外、体内和临床研究已经证实，NLC 可以增强各种类型药物在伤口愈合治疗中的治疗潜力。NLC 通过减小活性物质颗粒大小、提高溶解度和生物利用度以及延长药物释放来提高疗效，确保在慢性伤口中在伤口部位持续给予剂量。总之，NLC 是一种有效的纳米载体系统，可以优化伤口愈合过程中活性药理成分的生物利用度。
