Stojanov Aleksandar, Vojinovic Slobodan, Stojanov Jelena, Malobabic Marina, Stevic Milos, Milosevic Vuk, Stanojevic Goran
Neurology Clinic, University Clinical Center Nis, Serbia.
Neurology Clinic, University Clinical Center Nis, Serbia; Medical Faculty, University of Nis, Nis, Serbia.
Clin Neurol Neurosurg. 2021 Apr 14;205:106640. doi: 10.1016/j.clineuro.2021.106640.
ОBJECTIVE: Sleep disturbances and fatigue are frequent symptoms in multiple sclerosis patients. The aim was to assess the quality of sleep (QoS) and fatigue in patients with the relapsing-remitting multiple sclerosis (RRMS), during the coronavirus disease-2019 (COVID-19) pandemic.
The study included 67 patients with RRMS and 85 healthy control subjects. RRMS patients, who were tested in first half of 2019, were retested in April and May 2020, during the COVID-19 pandemic. We collected sociodemographic and clinical data, and also used the following questionnaires: Pittsburgh sleep quality index (PSQI), Fatigue Severity Scale (FSS), and Multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54).
The FSS score and PSQI global score were significantly higher in patients with RRMS than in the control group (p < 0.01). We noticed a statistically significant difference between the results obtained a year ago and the results during the COVID-19 pandemic in PSQI global score (p < 0.01) and all subscores. Higher disability status was an independent predictor of the worse PSQI scores.
During the COVID-19 outbreak worse QoS were noticed in RRMS patients than in healthy individuals. Also, QoS of RRMS patients is more affected during the COVID-19 pandemic than in regular circumstances. High levels of sleep disturbance and fatigue in RRMS patients correlates with worse life quality, female gender, lower educational level and partner status. The results of the present study provide evidence in support of regular screening and monitoring of fatigue and QoS in this patient population, especially during the pandemic states.
目的：睡眠障碍和疲劳是多发性硬化症患者常见的症状。本研究旨在评估复发缓解型多发性硬化症（RRMS）患者在2019年冠状病毒病（COVID-19）大流行期间的睡眠质量（QoS）和疲劳情况。
该研究纳入了67例RRMS患者和85名健康对照者。2019年上半年接受测试的RRMS患者在2020年4月和5月COVID-19大流行期间再次接受测试。我们收集了社会人口统计学和临床数据，并使用了以下问卷：匹兹堡睡眠质量指数（PSQI）、疲劳严重程度量表（FSS）和多发性硬化症生活质量-54量表（MSQOL-54）。
RRMS患者的FSS评分和PSQI总评分显著高于对照组（p < 0.01）。我们注意到，PSQI总评分（p < 0.01）及其所有子评分在一年前获得的结果与COVID-19大流行期间的结果之间存在统计学上的显著差异。较高的残疾状态是PSQI评分较差的独立预测因素。
在COVID-19疫情期间，RRMS患者的QoS比健康个体更差。此外，与正常情况相比，RRMS患者的QoS在COVID-19大流行期间受影响更大。RRMS患者高水平的睡眠障碍和疲劳与较差的生活质量、女性性别、较低的教育水平和伴侣状况相关。本研究结果为定期筛查和监测该患者群体的疲劳和QoS提供了证据支持，尤其是在大流行状态下。
