Wang Rongrong, Zhang Tengteng, Wang Han, Ren Yao, Zhao Runze, Zhang Gaopan, Zhang Guoxun, Zhao Xiongfei
Xianyang Hospital of Yan 'an University, Xianyang, China.
Xijing Hospital, Air Force Medical University, Xi'an, China.
Front Neurol. 2025 Jul 17;16:1608802. doi: 10.3389/fneur.2025.1608802. eCollection 2025.
Sleep disorders are a major but overlooked symptom in patients with multiple sclerosis (MS).
This article aims to investigate the characteristics of sleep disorders in patients with relapsing-remitting multiple sclerosis (RRMS) and to analyze the correlations between sleep disorders in RRMS and anxiety, depression, fatigue, and cognitive impairment.
A total of 35 patients with RRMS and 35 controls were included, and both groups underwent assessments for sleep, anxiety, depression, fatigue, and cognitive function.
The RRMS group and the control group showed significant differences in Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS), Insomnia Severity Index (ISI), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Modified Fatigue Impact Scale (MFIS), and Montreal Cognitive Assessment (MoCA). The group with poor sleep quality (PSQI > 5) had significantly higher scores on the AIS, ISI, HAMA, and HAMD Scale compared to the group with good sleep quality ( = 0.036, < 0.001, = 0.036, = 0.054). The PSQI showed a negative correlation with disease duration; the PSQI showed a positive correlation with HAMA, HAMD, and Activities of Daily Living (ADL); AIS, ISI, and Sleep Hygiene Awareness and Practice Scale (SHAPS) all demonstrated significant positive correlations with MFIS, HAMA, and HAMD; Dysfunctional Beliefs and Attitudes about Sleep Scale (DBAS) showed a negative correlation with HAMA and HAMD.
Sleep disorders, fatigue, anxiety, depression, and cognitive impairments are more likely to occur in patients with RRMS; there is a certain correlation between PSQI, AIS, ISI, SHAPS, and DBAS scores in the RRMS group and fatigue, anxiety, and depression.
睡眠障碍是多发性硬化症（MS）患者的一个主要但被忽视的症状。
本文旨在研究复发缓解型多发性硬化症（RRMS）患者睡眠障碍的特征，并分析RRMS患者睡眠障碍与焦虑、抑郁、疲劳和认知障碍之间的相关性。
共纳入35例RRMS患者和35例对照，两组均接受睡眠、焦虑、抑郁、疲劳和认知功能评估。
RRMS组和对照组在匹兹堡睡眠质量指数（PSQI）、雅典失眠量表（AIS）、失眠严重程度指数（ISI）、汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）、改良疲劳影响量表（MFIS）和蒙特利尔认知评估（MoCA）方面存在显著差异。睡眠质量差（PSQI>5）的组与睡眠质量好的组相比，在AIS、ISI、HAMA和HAMD量表上的得分显著更高（P=0.036，P<0.001，P=0.036，P=0.054）。PSQI与病程呈负相关；PSQI与HAMA、HAMD和日常生活活动（ADL）呈正相关；AIS、ISI和睡眠卫生意识与实践量表（SHAPS）均与MFIS、HAMA和HAMD呈显著正相关；睡眠功能失调信念和态度量表（DBAS）与HAMA和HAMD呈负相关。
RRMS患者更容易出现睡眠障碍、疲劳、焦虑、抑郁和认知障碍；RRMS组的PSQI、AIS、ISI、SHAPS和DBAS评分与疲劳、焦虑和抑郁之间存在一定的相关性。
