Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China; Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.
Biomed Pharmacother. 2021 Jul;139:111549. doi: 10.1016/j.biopha.2021.111549. Epub 2021 Apr 23.
The SIRT family of proteins constitutes highly conserved deacetylases with diverse and extensive functions. These proteins have specific biological functions, including regulation of transcription, cell cycle, cell differentiation, apoptosis, stress, metabolism, and genomic stability. Polydatin is a monocrystalline compound isolated from a Chinese herb, Polygonum cuspidatum. The pharmacological mechanisms of polydatin are mostly unclear but involve members of the SIRT protein family, among which SIRT1 plays a vital role. Polydatin is usually considered a potential SIRT1 activator. This review summarizes the signaling mechanism of polydatin involving SIRT1 and discusses the roles of related signal molecules such as PGC-1α, Nrf2, p38-MAPK, NLPR3 inflammasome, and p53. Further, we describe the metabolic regulation of related biological macromolecules and demonstrate that SIRT1, as a metabolic sensor, may act as a new pharmacological target for polydatin.
SIRT 蛋白家族构成高度保守的去乙酰化酶，具有多样且广泛的功能。这些蛋白质具有特定的生物学功能，包括转录调控、细胞周期、细胞分化、细胞凋亡、应激、代谢和基因组稳定性。白藜芦醇是从中国草药虎杖中分离得到的一种单晶化合物。白藜芦醇的药理机制大多不清楚，但涉及 SIRT 蛋白家族成员，其中 SIRT1 起着至关重要的作用。白藜芦醇通常被认为是一种潜在的 SIRT1 激活剂。本综述总结了涉及 SIRT1 的白藜芦醇的信号转导机制，并讨论了相关信号分子如 PGC-1α、Nrf2、p38-MAPK、NLPR3 炎性小体和 p53 的作用。此外，我们描述了相关生物大分子的代谢调控，并表明 SIRT1 作为代谢传感器，可能成为白藜芦醇的一个新的药理学靶点。
