Department of Clinical Laboratory, Affiliated People's Hospital of Shanxi Medical University, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Department of Laboratory Medicine, Shanxi Medical University, Taiyuan, Shanxi, China.
J Physiol Pharmacol. 2020 Dec;71(6). doi: 10.26402/jpp.2020.6.10. Epub 2021 Apr 22.
Serum levels of human epididymis protein 4 (HE4) are elevated in a large number of women with chronic kidney disease (CKD). However, it remains unclear whether HE4 can be used as a potential biomarker for the diagnosis of CKD. This study aims to determine whether serum HE4 is a potential biomarker for CKD in Han Chinese female patients. A total of 347 Han Chinese female patients aged 19 to 89 were included in the present study. Among these patients, 154 were healthy control individuals, while 193 were hospitalized patients with CKD. Their demographic characteristics were obtained, and the levels of serum creatinine (Scr), beta2-microglobulin (B2M), and cystatin C (CysC) (to assess renal function) were measured. Serum HE4 concentration was determined by electrochemiluminescence. Serum HE4 levels in patients with CKD were significantly higher than those in the control group (P < 0.001). Meanwhile, there were significant differences in HE4 levels among the four CKD subgroups (P < 0.001) via multiple comparisons. In addition, the diagnostic value of HE4 was significantly higher than other indicators by ROC curve analysis. HE4 may not only serve as a potential biomarker to predict CKD but also have an important reference value for CKD staging.
血清人附睾蛋白 4（HE4）水平在大量患有慢性肾脏病（CKD）的女性中升高。然而，目前尚不清楚 HE4 是否可作为 CKD 诊断的潜在生物标志物。本研究旨在确定血清 HE4 是否为汉族女性 CKD 患者的潜在生物标志物。本研究共纳入 347 名年龄在 19 至 89 岁的汉族女性患者。其中 154 名健康对照组，193 名住院 CKD 患者。记录其人口统计学特征，并检测血清肌酐（Scr）、β2-微球蛋白（B2M）和胱抑素 C（CysC）（用于评估肾功能）水平。采用电化学发光法测定血清 HE4 浓度。CKD 患者的血清 HE4 水平明显高于对照组（P<0.001）。此外，通过多重比较，四个 CKD 亚组之间的 HE4 水平也存在显著差异（P<0.001）。此外，通过 ROC 曲线分析，HE4 的诊断价值明显高于其他指标。HE4 不仅可能作为预测 CKD 的潜在生物标志物，而且对 CKD 分期也具有重要的参考价值。
