Department of Ophthalmology, University of Basel, Basel, Switzerland.
Department of Ophthalmology, Centre of Postgraduate Medical Education, Warsaw, Poland.
J Physiol Pharmacol. 2020 Dec;71(6). doi: 10.26402/jpp.2020.6.13. Epub 2021 Apr 22.
The aim of the study was to investigate the endothelin-1 (ET-1) plasma level and its age dependence in patients with normal tension glaucoma (NTG), high tension glaucoma (HTG), and healthy controls. In blood samples from 35 NTG patients, 34 HTG patients, and 36 controls, ET-1 plasma levels were determined by enzyme-linked immunosorbent assay (ELISA). After adjustment for age and gender, the mean ET-1 levels were found to be similar in all three study groups. The age dependency however was highest in NTGs and significantly different from that of the controls. For the HTGs, this dependence was weaker and not significantly different from that of the controls. Our findings suggest that age had a significantly greater influence on ET plasma level in the NTG patients than in the HTG patients and controls. This supports previous reports indicating that ET plays a role in the pathogenesis of glaucoma, and in particular normal NTG.
本研究旨在探讨正常眼压性青光眼（NTG）、高眼压性青光眼（HTG）患者及健康对照者的血浆内皮素-1（ET-1）水平及其与年龄的关系。采用酶联免疫吸附试验（ELISA）法检测 35 例 NTG 患者、34 例 HTG 患者及 36 例对照组的 ET-1 血浆水平。经年龄和性别校正后，三组研究对象的平均 ET-1 水平相似。然而，NTG 组的年龄依赖性最高，与对照组有显著差异。HTG 组的依赖性较弱，与对照组无显著差异。我们的研究结果表明，年龄对 NTG 患者 ET 血浆水平的影响明显大于 HTG 患者和对照组。这支持了先前的研究报告，表明 ET 在青光眼的发病机制中起重要作用，特别是在正常 NTG 中。
