母亲在牙买加儿童自闭症谱系障碍中的暴露情况。
Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children.
机构信息
Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Biostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX, USA.
出版信息
J Autism Dev Disord. 2018 Aug;48(8):2766-2778. doi: 10.1007/s10803-018-3537-6.
Abstract
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD.
摘要
自闭症谱系障碍（ASD）是一种复杂的神经发育障碍，其病因尚不清楚。许多孕妇在怀孕期间和哺乳期的暴露可能会干扰神经发育。利用来自牙买加的两项年龄和性别匹配的病例对照研究的数据（n=298 对），条件逻辑回归分析的结果表明，母亲发热或感染（匹配优势比（MOR）=3.12，95%置信区间 1.74-5.60）、身体创伤（MOR=2.02，95%置信区间 1.01-4.05）和油性油漆（MOR=1.99，95%置信区间 1.14-3.46）可能与 ASD 有关。此外，母亲接触油性油漆可能会改变母亲接触杀虫剂与 ASD 之间的关系，这加深了我们对杀虫剂与 ASD 之间关系的理解。
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