Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Biostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX, USA.
J Autism Dev Disord. 2018 Aug;48(8):2766-2778. doi: 10.1007/s10803-018-3537-6.
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD.
自闭症谱系障碍（ASD）是一种复杂的神经发育障碍，其病因尚不清楚。许多孕妇在怀孕期间和哺乳期的暴露可能会干扰神经发育。利用来自牙买加的两项年龄和性别匹配的病例对照研究的数据（n=298 对），条件逻辑回归分析的结果表明，母亲发热或感染（匹配优势比（MOR）=3.12，95%置信区间 1.74-5.60）、身体创伤（MOR=2.02，95%置信区间 1.01-4.05）和油性油漆（MOR=1.99，95%置信区间 1.14-3.46）可能与 ASD 有关。此外，母亲接触油性油漆可能会改变母亲接触杀虫剂与 ASD 之间的关系，这加深了我们对杀虫剂与 ASD 之间关系的理解。
