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童年丧父与青年时期血压:一项基于瑞典男性人群的队列研究

Death of a parent during childhood and blood pressure in youth: a population-based cohort study of Swedish men.

作者信息

Chen Hua, Hemmingsson Tomas, Janszky Imre, Rostila Mikael, Forsell Yvonne, Meng Linghui, Liang Yajun, László Krisztina D

机构信息

Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden

Department of Public Health Sciences, Stockholm University, Stockholm, Sweden.

出版信息

BMJ Open. 2021 Apr 26;11(4):e043657. doi: 10.1136/bmjopen-2020-043657.

Abstract

OBJECTIVE

Compelling evidence suggests that childhood adversities are associated with an increased risk of hypertension in middle age and old age. The link between childhood adversities and blood pressure in youth is less clear. In this cohort study, we examined the association between death of a parent during childhood and blood pressure in early adulthood in men.

SETTING

Sweden.

PARTICIPANTS

We studied 48 624 men born in 1949-1951 who participated in the compulsory military conscription in 1969/1970 in Sweden. Information on death of a parent during childhood was obtained from population-based registers. Information on covariates was obtained from the questionnaire and the clinical examination completed at conscription and from population-based registers.

OUTCOME MEASURES

Blood pressure was measured at conscription according to standard procedures.

RESULTS

The multivariable least square means of systolic and diastolic blood pressure did not differ between bereaved (128.25 (127.04-129.46) and 73.86 (72.89-74.84) mm Hg) and non-bereaved study participants (128.02 (126.86-129.18) and 73.99 (73.06-74.93) mm Hg). Results were similar when considering the cause of the parent's death, the gender of the deceased parent or the child's age at loss. Loss of a parent in childhood tended to be associated with an increased hypertension risk (OR and 95% CI: 1.10 (1 to 1.20)); the association was present only in case of natural deaths.

CONCLUSION

We found no strong support for the hypothesis that stress following the loss of a parent during childhood is associated with blood pressure or hypertension in youth in men.

摘要

目的

有力证据表明,童年逆境与中老年患高血压风险增加有关。童年逆境与青年血压之间的联系尚不清楚。在这项队列研究中,我们调查了童年时期父亲或母亲死亡与男性成年早期血压之间的关联。

研究地点

瑞典。

参与者

我们研究了1949年至1951年出生、于1969/1970年参加瑞典义务兵役制的48624名男性。童年时期父母死亡的信息来自基于人群的登记册。协变量信息来自征兵时填写的问卷、临床检查以及基于人群的登记册。

观察指标

征兵时按照标准程序测量血压。

结果

父母丧亡组(收缩压和舒张压的多变量最小二乘均值分别为128.25(127.04 - 129.46)和73.86(72.89 - 74.84)mmHg)与非丧亲组研究参与者(收缩压和舒张压的多变量最小二乘均值分别为128.02(126.86 - 129.18)和73.99(73.06 - 74.93)mmHg)之间无差异。在考虑父母死亡原因、已故父母性别或丧亲时孩子的年龄时,结果相似。童年丧亲往往与高血压风险增加相关(比值比及95%置信区间:1.10(1至1.20));仅在自然死亡的情况下存在这种关联。

结论

我们没有找到有力证据支持童年丧亲后的压力与男性青年期血压或高血压有关这一假设。

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