刺激脑桥被盖区选择性地调节人类的疼痛。
Stimulation of zona incerta selectively modulates pain in humans.
机构信息
Department of Neurosurgery, University of Michigan, 1500 E Medical Center Drive, SPC 5338, Ann Arbor, MI, 48109-5338, USA.
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
出版信息
Sci Rep. 2021 Apr 26;11(1):8924. doi: 10.1038/s41598-021-87873-w.
Stimulation of zona incerta in rodent models has been shown to modulate behavioral reactions to noxious stimuli. Sensory changes observed in Parkinsonian patients with subthalamic deep brain stimulation suggest that this effect is translatable to humans. Here, we utilized the serendipitous placement of subthalamic deep brain stimulation leads in 6 + 5 Parkinsonian patients to directly investigate the effects of zona incerta stimulation on human pain perception. We found that stimulation at 20 Hz, the physiological firing frequency of zona incerta, reduces experimental heat pain by a modest but significant amount, achieving a 30% reduction in one fifth of implants. Stimulation at higher frequencies did not modulate heat pain. Modulation was selective for heat pain and was not observed for warmth perception or pressure pain. These findings provide a mechanistic explanation of sensory changes seen in subthalamic deep brain stimulation patients and identify zona incerta as a potential target for neuromodulation of pain.
在啮齿动物模型中刺激缰核已被证明可以调节对有害刺激的行为反应。接受丘脑底核深部脑刺激的帕金森病患者观察到的感觉变化表明，这种效应可以在人类中转化。在这里，我们利用丘脑底核深部脑刺激导联在 6+5 名帕金森病患者中的偶然放置，直接研究缰核刺激对人类疼痛感知的影响。我们发现，以 20 Hz 的频率刺激，即缰核的生理放电频率，可适度但显著地减轻实验性热痛，在五分之一的植入物中实现了 30%的减轻。较高频率的刺激不会调节热痛。调节是热痛的选择性调节，在温暖感知或压痛时观察不到。这些发现为丘脑底核深部脑刺激患者中观察到的感觉变化提供了一种机制解释，并确定缰核作为疼痛神经调节的潜在靶点。
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