低频双侧间脑深部电刺激治疗震颤合并小脑性共济失调患者的疗效。
Effects of Low-Frequency Deep Brain Stimulation in Bilateral Zona Incerta for a Patient With Tremor and Cerebellar Ataxia.
机构信息
Department of Neurology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, USA.
Initiative for Columbia Ataxia and Tremor, Columbia University Irving Medical Center, New York, NY, USA.
出版信息
Tremor Other Hyperkinet Mov (N Y). 2024 Aug 21;14:42. doi: 10.5334/tohm.925. eCollection 2024.
BACKGROUND
Whether low-frequency deep brain stimulation (DBS) in the caudal zona incerta (cZi) can improve cerebellar ataxia symptoms remains unexplored.
CASE REPORT
We report a 66-year-old man initially diagnosed with essential tremor and subsequently developed cerebellar ataxia after bilateral cZi DBS implantation. We tested the effects of low-frequency DBS stimulations (sham, 10 Hz, 15 Hz, 30 Hz) on ataxia severity.
DISCUSSION
Low-frequency cZi DBS improves ataxic speech at 30 Hz, but not at 10 Hz or 15 Hz in this patient. Low-frequency DBS did not improve gait or stance. Therefore, low-frequency stimulation may play a role in treating ataxic speech.
HIGHLIGHTS
The finding of this case study suggests that bilateral low-frequency DBS at 30 Hz in the caudal zona incerta has the potential to improve ataxic speech but has limited impact on gait and stance. The involvement of zona incerta in speech warrants further investigation.
背景
低频深部脑刺激（DBS）在尾状核下区（cZi）是否能改善小脑性共济失调症状尚不清楚。
病例报告
我们报告了一例 66 岁男性，最初诊断为特发性震颤，随后在双侧 cZi DBS 植入后出现小脑性共济失调。我们测试了低频 DBS 刺激（假刺激、10Hz、15Hz、30Hz）对共济失调严重程度的影响。
讨论
低频 cZi DBS 可改善患者的共济失调性言语，在 30Hz 时，但在 10Hz 或 15Hz 时则不然。低频 DBS 并未改善步态或站立姿势。因此，低频刺激可能在治疗共济失调性言语方面发挥作用。
重点
这项病例研究的发现表明，双侧低频 30Hz DBS 在尾状核下区可能有改善共济失调性言语的潜力，但对步态和站立姿势的影响有限。尾状核下区在言语中的作用值得进一步研究。
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