Division of Thoracic & Cardiovascular Surgery, Department of Surgery, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
Division of Respiratory Medicine, Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
West Afr J Med. 2021 Apr 23;38(4):380-386.
Lung cancer incidence and mortality rates have increased in some low and medium-resourced countries.
This study aimed to describe the clinicopathological pattern and management of lung cancer seen in our setting.
We reviewed cases of pulmonary neoplasm diagnosed and managed at the University of Ilorin teaching hospital over eight years. Cases with tissue diagnosis were enrolled in the study and relevant clinical data were collected from the medical record using a proforma.
Hospital-based retrospective study.
Out of the 71 cases of primary lung cancer reviewed, 44(62%) were males and the male to female ratio was 2:1. The mean age was 62±14 years and the occurrence was highest in aged 50-69 years. Thirty (42.3%) with histories of tobacco smoking were males. Adenocarcinoma accounted for 34(54.9%), 23(32.4%) were squamous cell carcinoma, 2(2.8%) were large cell carcinoma and 6(8.5%) were other histological variants. The majority (82.7%) presented at stage III-IV lung cancers, 56.3% had malignant pleural effusion and 74.6% received palliative care. Thirty-eight (53.3%) had chest tube drainage, 19(26.7%) underwent chemical pleurodesis and 22(31.0%) received Cisplatin-based systemic chemotherapy. One patient had curative surgery and none received radiotherapy. At 12 months, 4 (5.6%) were still alive, 14(19.7%) cases had medical records of their death and 53(74.7%) were lost to follow up.
This study has highlighted the clinicopathological trend, high rate of mortality and late presentation of lung cancer in our setting. There is a need to increase the awareness of the warning signs and risk factors to ensure early detection and facilitate curative therapy.
在一些中低收入国家，肺癌的发病率和死亡率有所上升。
本研究旨在描述我们研究环境中所见的肺癌的临床病理模式和管理。
我们回顾了在伊洛林大学教学医院诊断和治疗的 8 年期间的肺部肿瘤病例。对有组织诊断的病例进行了研究，并使用表格从病历中收集了相关的临床数据。
基于医院的回顾性研究。
在审查的 71 例原发性肺癌中，44 例（62%）为男性，男女比例为 2:1。平均年龄为 62±14 岁，发病率最高的是 50-69 岁年龄段。30 例（42.3%）有吸烟史的男性。腺癌占 34 例（54.9%），鳞状细胞癌占 23 例（32.4%），大细胞癌占 2 例（2.8%），其他组织学变异占 6 例（8.5%）。大多数（82.7%）处于 III-IV 期肺癌，56.3%有恶性胸腔积液，74.6%接受姑息治疗。38 例（53.3%）行胸腔引流管引流，19 例（26.7%）行化学性胸膜固定术，22 例（31.0%）接受顺铂为基础的全身化疗。1 例患者接受了根治性手术，没有患者接受放疗。在 12 个月时，4 例（5.6%）仍存活，14 例（19.7%）有死亡记录，53 例（74.7%）失访。
本研究突出了我们研究环境中的肺癌临床病理趋势、高死亡率和晚期表现。需要提高对警告症状和危险因素的认识，以确保早期发现并促进根治性治疗。
