Fraser R, Clark S A, Day W A, Murray F E
Department of Pathology, Christchurch School of Medicine, New Zealand.
Br J Exp Pathol. 1988 Jun;69(3):345-50.
Nicotine was fed to rats for 6 weeks, as a weight adjusted dose equivalent to that of a human being smoking 50 to 100 cigarettes per day. Those rats fed nicotine developed hypercholesterolaemia. Scanning electron microscopy showed the porosity of the hepatic sinusoidal endothelium of nicotine fed animals was about 40% that of control animals. The decline in porosity was found to be due to a reduction in diameter rather than number of fenestrae. We believe that this decreased hepatic sinusoidal porosity may alter cholesterol homeostasis by increasing the circulation time of chylomicron remnants too large to pass through the fenestrae. This phenomenon may be an aetiological factor in the known correlation between cigarette smoking, atherosclerosis, and coronary heart disease in humans.
给大鼠喂食尼古丁6周，剂量按体重调整，相当于人类每天吸食50至100支香烟的剂量。那些喂食尼古丁的大鼠出现了高胆固醇血症。扫描电子显微镜显示，喂食尼古丁的动物肝窦内皮的孔隙率约为对照动物的40%。发现孔隙率的下降是由于窗孔直径减小而非数量减少。我们认为，肝窦孔隙率降低可能通过增加太大而无法穿过窗孔的乳糜微粒残余物的循环时间来改变胆固醇稳态。这种现象可能是人类吸烟、动脉粥样硬化和冠心病之间已知关联的一个病因因素。
