Wu Jin-Yun, Liu Hong-Zhi, Qi Yan-Qing, Wu Xiao-Yang, Chen Yang, Lyu Jiang-Teng, Gong Ling, He Miao
Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Shanghai Jiao Tong University College of Basic Medical Sciences, Shanghai 200025, China.
Sheng Li Xue Bao. 2021 Apr 25;73(2):295-305.
Cortical GABAergic inhibitory neurons are composed of three major classes, each expressing parvalbumin (PV), somatostatin (SOM) and 5-hydroxytryptamine receptor 3A (Htr3a), respectively. Htr3a inhibitory neurons are mainly derived from the caudal ganglionic eminence (CGE). This highly heterogeneous group of inhibitory neurons are comprised of many different subtypes with distinct molecular signatures, morphological and electrophysiological properties and connectivity patterns. In this review, we summarized recent research progress regarding cortical Htr3a inhibitory neurons, focusing on their molecular, morphological and electrophysiological diversity, and introduced some genetic mouse tools that were used to study Htr3a inhibitory neurons.
皮质GABA能抑制性神经元由三大类组成，每一类分别表达小白蛋白（PV）、生长抑素（SOM）和5-羟色胺受体3A（Htr3a）。Htr3a抑制性神经元主要来源于尾侧神经节隆起（CGE）。这群高度异质性的抑制性神经元由许多不同的亚型组成，这些亚型具有不同的分子特征、形态和电生理特性以及连接模式。在这篇综述中，我们总结了关于皮质Htr3a抑制性神经元的最新研究进展，重点关注它们的分子、形态和电生理多样性，并介绍了一些用于研究Htr3a抑制性神经元的基因工程小鼠工具。
