偏头痛伴 APT1A2 突变患者的认知功能障碍：病例报告。
Cognitive dysfunction in a patient with migraine and APT1A2 mutation: a case report.
机构信息
Department of Neurology, Chengdu Fifth Peoples' Hospital, No 33, Mashi Road, Wenjiang, Chengdu, Sichuan, People's Republic of China.
出版信息
Neurol Sci. 2021 Dec;42(12):5425-5431. doi: 10.1007/s10072-021-05284-1. Epub 2021 Apr 27.
BACKGROUND
Hemiplegic migraine (HM) is a rare type of migraine with aura. Some reports have described the clinical manifestations in HM patients with the ATP1A2 mutation. But the impact of the ATP1A2 mutation on cognitive profile in HM patients has not been evaluated in detail. Here we report a patient with cognitive dysfunction in specific area.
CASE PRESENTATION
A 15-year-old boy with an aura that included disturbances in consciousness, associated with fever, vomiting, hemiplegia, and aphasia. He was diagnosed with HM with the ATP1A2 mutation before. He had trouble in mathematics and depicting three-dimensional things.
CONCLUSIONS
The HM with ATP1A2 patient could develop permanent cognitive dysfunction. Therefore, the cognitive quotient should be carefully and comprehensively evaluated.
背景
偏瘫性偏头痛（HM）是一种罕见的伴有先兆的偏头痛类型。一些报道描述了 ATP1A2 突变的 HM 患者的临床表现。但是，ATP1A2 突变对 HM 患者认知特征的影响尚未详细评估。在这里，我们报告了一例认知功能障碍的患者。
病例介绍
一名 15 岁男孩，有先兆，包括意识障碍，伴有发热、呕吐、偏瘫和失语。他以前被诊断为伴有 ATP1A2 突变的 HM。他在数学和描绘三维物体方面有困难。
结论
伴有 ATP1A2 突变的 HM 患者可能会出现永久性认知功能障碍。因此，应仔细和全面地评估认知商数。
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