Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Neurovirol. 2021 Jun;27(3):504-506. doi: 10.1007/s13365-021-00978-w. Epub 2021 Apr 26.
COVID-19 encephalitis is a rare condition usually presenting with altered mental status. Simultaneous presence of anti-NMDAR antibody and SARS-CoV-2 virus in CSF is a very rare condition described in a few case reports so far. On the other hand, brain edema is an unusual presentation of anti-NMDAR encephalitis. Herein, we reported a case with simultaneous detection of anti-NMDAR antibody and SARS-CoV-2 virus in her cerebrospinal fluid (CSF) presenting with brain edema, altered mental status, seizures, and respiratory symptoms.
COVID-19 脑炎是一种罕见的疾病,通常表现为精神状态改变。到目前为止,只有少数病例报告中描述了同时存在抗 NMDAR 抗体和 SARS-CoV-2 病毒于脑脊液中的这种非常罕见的情况。另一方面,脑水肿是抗 NMDAR 脑炎的一种不常见表现。在此,我们报告了一例同时检测到抗 NMDAR 抗体和 SARS-CoV-2 病毒于脑脊液中的病例,该患者表现为脑水肿、精神状态改变、癫痫发作和呼吸系统症状。