Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mol Biol Rep. 2020 Jul;47(7):5365-5376. doi: 10.1007/s11033-020-05621-1. Epub 2020 Jun 29.
Emerging of the COVID-19 pandemic has raised interests in the field of biology and pathogenesis of coronaviruses; including interactions between host immune reactions specific, and viral factors. Deep knowledge about the interaction between coronaviruses and the host factors could be useful to provide a better support for the disease sufferers and be advantageous for managing and treatment of the lung infection caused by the virus. At this study, we reviewed the updated information on the pathogenesis of the COVID-19 and the immune responses toward it, with a special focus on structure, genetics, and viral accessory proteins, viral replication, viral receptors, the human immune reactions, cytopathic effects, and host-related factors.
新冠疫情的爆发引起了人们对冠状病毒生物学和发病机制的兴趣；包括宿主免疫反应特异性和病毒因素之间的相互作用。深入了解冠状病毒与宿主因素之间的相互作用，可以为患者提供更好的支持，有利于管理和治疗病毒引起的肺部感染。在本研究中，我们回顾了 COVID-19 的发病机制和免疫反应的最新信息，特别关注结构、遗传学和病毒辅助蛋白、病毒复制、病毒受体、人体免疫反应、细胞病变效应和宿主相关因素。
