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新生儿格雷夫斯病

Neonatal Graves' disease.

作者信息

Shields C L, Nelson L B, Carpenter G C, Shields J A

机构信息

Pediatric Ophthalmology Service, Wills Eye Hospital, Philadelphia, PA 19107.

出版信息

Br J Ophthalmol. 1988 Jun;72(6):424-7. doi: 10.1136/bjo.72.6.424.

DOI:10.1136/bjo.72.6.424
PMID:3390416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1041474/
Abstract

A newborn boy was noted by his mother to have a prominent left eye at birth, but an eye examination was delayed until age 7 months, at which time his ophthalmologist diagnosed exophthalmos. Computed tomography was interpreted as showing mild, diffuse, optic nerve thickening bilaterally suggestive of optic nerve gliomas. Subsequent examination in our clinic revealed pseudoproptosis secondary to retraction of the left upper eyelid. Magnetic resonance imaging demonstrated normal orbital structures. The mother was noted to be clinically hyperthyroid, and abnormal thyroid function tests confirmed the diagnosis. Although the infant was euthyroid, neonatal Graves' ophthalmopathy was diagnosed. He was managed by close observation while his mother was treated for her hyperthyroidism.

摘要

一位男婴出生时,其母亲就注意到他的左眼突出,但眼部检查推迟到了7个月大时进行,当时他的眼科医生诊断为眼球突出。计算机断层扫描显示双侧视神经轻度、弥漫性增厚,提示视神经胶质瘤。随后在我们诊所的检查发现,左眼上睑退缩继发假性眼球突出。磁共振成像显示眼眶结构正常。注意到患儿母亲临床上有甲状腺功能亢进,甲状腺功能检查异常证实了诊断。尽管婴儿甲状腺功能正常,但仍诊断为新生儿格雷夫斯眼病。在其母亲接受甲状腺功能亢进治疗的同时,对婴儿进行密切观察。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c3/1041474/9f65a43b2382/brjopthal00610-0026-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c3/1041474/a52b8d7fb329/brjopthal00610-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c3/1041474/84ec80622d31/brjopthal00610-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c3/1041474/9f65a43b2382/brjopthal00610-0026-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c3/1041474/a52b8d7fb329/brjopthal00610-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c3/1041474/84ec80622d31/brjopthal00610-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59c3/1041474/9f65a43b2382/brjopthal00610-0026-b.jpg

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Neonatal Graves' disease.新生儿格雷夫斯病
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引用本文的文献

1
Congenital eyelid retraction.先天性眼睑退缩
Br J Ophthalmol. 1990 Sep;74(9):542-4. doi: 10.1136/bjo.74.9.542.

本文引用的文献

1
Obstetrics and gynaecology in relation to thyrotoxicosis and myasthenia gravis.与甲状腺毒症和重症肌无力相关的妇产科学
J Obstet Gynaecol Br Emp. 1952 Apr;59(2):173-82. doi: 10.1111/j.1471-0528.1952.tb04112.x.
2
Graves' ophthalmopathy. A clinical and immunologic review.格雷夫斯眼病。临床与免疫学综述。
Surv Ophthalmol. 1981 Jul-Aug;26(1):1-21. doi: 10.1016/0039-6257(81)90120-x.
3
Pregnancy-associated changes in the thyroid-stimulating antibody of Graves' disease and the relationship to neonatal hyperthyroidism.格雷夫斯病促甲状腺素抗体的妊娠相关变化及其与新生儿甲状腺功能亢进症的关系。
J Clin Endocrinol Metab. 1983 Nov;57(5):1036-40. doi: 10.1210/jcem-57-5-1036.
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Graves' disease in Olmsted County, Minnesota, 1935 through 1967.
Mayo Clin Proc. 1970 Sep;45(9):636-44.
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Hereditary aspects of Graves' disease in infancy and childhood.婴幼儿及儿童期格雷夫斯病的遗传因素
J Pediatr. 1972 Sep;81(3):446-59. doi: 10.1016/s0022-3476(72)80170-7.
6
Prediction and therapy of intrauterine and late-onset neonatal hyperthyroidism.宫内及迟发性新生儿甲状腺功能亢进症的预测与治疗
J Clin Endocrinol Metab. 1986 Feb;62(2):368-71. doi: 10.1210/jcem-62-2-368.
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The pathogenesis of Graves' disease.格雷夫斯病的发病机制。
Clin Endocrinol Metab. 1985 May;14(2):299-330. doi: 10.1016/s0300-595x(85)80036-0.
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Editorial: Medical jargon.社论:医学术语
JAMA. 1976 Mar 15;235(11):1149. doi: 10.1001/jama.235.11.1149.
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Hyperthyroidism in childhood.儿童期甲状腺功能亢进症
Clin Endocrinol Metab. 1978 Mar;7(1):127-43. doi: 10.1016/s0300-595x(78)80039-5.