Liggins Institute, The University of Auckland, Auckland, New Zealand.
Department of Physiology, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand.
Mol Reprod Dev. 2021 May;88(5):321-337. doi: 10.1002/mrd.23430. Epub 2021 Apr 26.
Cytokines are important regulators of pregnancy and parturition. Aberrant expression of proinflammatory cytokines during pregnancy contributes towards preterm labor, pre-eclampsia, and gestational diabetes mellitus. The regulation of cytokine expression in human cells is highly complex, involving interactions between environment, transcription factors, and feedback mechanisms. Recent developments in epigenetic research have made tremendous advancements in exploring histone modifications as a key epigenetic regulator of cytokine expression and the effect of their signaling molecules on various organ systems in the human body. Histone acetylation and subsequent deacetylation by histone deacetylases (HDACs) are major epigenetic regulators of protein expression in the human body. The expression of various proinflammatory cytokines, their role in normal and abnormal pregnancy, and their epigenetic regulation via HDACs will be discussed in this review.
细胞因子是妊娠和分娩的重要调节因子。妊娠期间促炎细胞因子的异常表达可导致早产、子痫前期和妊娠糖尿病。人细胞中细胞因子表达的调控非常复杂，涉及环境、转录因子和反馈机制之间的相互作用。表观遗传学研究的最新进展在探索组蛋白修饰作为细胞因子表达的关键表观遗传调节剂以及其信号分子对人体各种器官系统的影响方面取得了巨大进展。组蛋白乙酰化及其随后由组蛋白去乙酰化酶 (HDACs) 进行的去乙酰化是人体中蛋白质表达的主要表观遗传调节剂。本综述将讨论各种促炎细胞因子的表达、它们在正常和异常妊娠中的作用以及它们通过 HDACs 的表观遗传调控。
