Second Department of Dermatology and Venereology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Iran J Allergy Asthma Immunol. 2021 Apr 17;20(2):255-259.
Generalized bullous fixed drug eruption (GBFDE) is a specific variant of fixed drug eruption that belongs to severe cutaneous adverse reactions (SCARs) and its diagnosis is based mainly on clinical course and especially on the reoccurrence of typical bullous lesions in previous and new sites after re-administration of the offending drug. We present a well-documented case of fluconazole-induced GBFDE, with a positive patch test to fluconazole (30% weight/volume preparation) and clinical tolerance to itraconazole proven by negative oral provocation. Even in SCARs, patch testing represents a useful diagnostic tool, while oral provocation remains the gold standard in cases that an alternative but the chemically relevant drug must be administered.
泛发性大疱性固定性药疹（GBFDE）是固定性药疹的一种特殊类型，属于严重皮肤不良反应（SCARs），其诊断主要基于临床病程，特别是在重新给予致病药物后，先前和新部位出现典型大疱性病变的复发。我们报告了一例氟康唑诱导的 GBFDE，氟康唑（30%重量/体积制剂）斑贴试验阳性，伊曲康唑口服激发试验阴性证实其临床耐受。即使在 SCARs 中，斑贴试验也是一种有用的诊断工具，而口服激发试验仍然是在必须给予替代但化学相关药物的情况下的金标准。
