Grosberg A Iu, Nechaev S K, Shakhnovich E I
Biofizika. 1988 Mar-Apr;33(2):247-53.
Fast collapse of a linear homopolymer after a spasmodic temperature decrease or deterioration of the solvent quality results in the initiation of folded nonequilibrium globule. The chain line in it is a fractal with the dimension mu less than or equal to 2 at small ranges and 3 at the large ones. This is provided by non-selfintersection of the chain and initiated therefore spatial segregation from each other at all the ranges of the chain regions, globulized each in itself. Further relaxation of the folded globule proceeds very slowly only at the expense of reptation (diffusion crawling) of the chain along itself, and results in the polymer knotting. The model of the folded globule permits explanation from a single viewpoint of a number of globular proteins properties. Predictions are formulated whose checking in a real or computer experiment should reveal the adequacy of our results.
在温度急剧下降或溶剂质量恶化后，线性均聚物迅速塌陷，导致折叠非平衡球状体的形成。其中的链线是一种分形，在小范围内维度μ小于或等于2，在大范围内为3。这是由链的非自相交提供的，因此在链区域的所有范围内，链彼此之间开始空间隔离，各自形成球状。折叠球状体的进一步弛豫非常缓慢，仅以链沿自身的蠕动（扩散爬行）为代价，结果导致聚合物打结。折叠球状体模型允许从单一观点解释许多球状蛋白质的性质。提出了一些预测，在实际或计算机实验中对其进行检验应能揭示我们结果的充分性。
