Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Division of Clinical Immunology and Cancer Immunotherapy, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hum Cell. 2021 Jul;34(4):1031-1039. doi: 10.1007/s13577-021-00514-2. Epub 2021 Apr 27.
Malignant tumors comprise various types of normal cells and tumor cells, and are infiltrated by large numbers of immune cells, including macrophages. The results of numerous studies on the function and significance of intratumoral macrophages (tumor-associated macrophages) suggest that these macrophages generally enhance tumor progression rather than act as anti-tumor immune agents. Although much remains unknown, in this review, we attempt to describe the role of macrophages in the tumor microenvironment, and discuss their potential mechanisms on the recent immunotherapy.
恶性肿瘤由各种类型的正常细胞和肿瘤细胞组成，并被大量免疫细胞浸润，包括巨噬细胞。大量关于肿瘤内巨噬细胞（肿瘤相关巨噬细胞）功能和意义的研究结果表明，这些巨噬细胞通常促进肿瘤进展，而不是作为抗肿瘤免疫剂发挥作用。尽管仍有许多未知因素，但在本综述中，我们试图描述巨噬细胞在肿瘤微环境中的作用，并讨论它们在最近的免疫治疗中的潜在机制。
