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Selective hypermethylation is evident in small intestine samples from infants with necrotizing enterocolitis.选择性高甲基化在患有坏死性小肠结肠炎的婴儿的小肠样本中是明显的。
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本文引用的文献

1
Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis.肠道上皮细胞的全球甲基化是新生儿手术性坏死性小肠结肠炎的一个显著特征。
Clin Epigenetics. 2020 Dec 11;12(1):190. doi: 10.1186/s13148-020-00983-6.
2
Loss of the Krüppel-like factor 4 tumor suppressor is associated with epithelial-mesenchymal transition in colorectal cancer.Krüppel样因子4肿瘤抑制因子的缺失与结直肠癌的上皮-间质转化相关。
J Cancer Metastasis Treat. 2019;5. doi: 10.20517/2394-4722.2019.35. Epub 2019 Nov 26.
3
Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population.多靶点粪便 DNA 检测在一般风险结直肠癌筛查人群中的性能。
Am J Gastroenterol. 2019 Dec;114(12):1909-1918. doi: 10.14309/ajg.0000000000000445.
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Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis.Wnt/β-catenin 通路功能障碍导致坏死性小肠结肠炎时肠道再生功能障碍。
Cell Death Dis. 2019 Oct 3;10(10):743. doi: 10.1038/s41419-019-1987-1.
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Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans.系统性炎症会导致小鼠和人类造血细胞和实质细胞释放游离细胞 DNA。
Blood Adv. 2019 Mar 12;3(5):724-728. doi: 10.1182/bloodadvances.2018018895.
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Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease.微生物无细胞 DNA 测序检测用于感染性疾病的分析和临床验证。
Nat Microbiol. 2019 Apr;4(4):663-674. doi: 10.1038/s41564-018-0349-6. Epub 2019 Feb 11.
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Noninvasive blood tests for fetal development predict gestational age and preterm delivery.非侵入性胎儿发育血液检测可预测胎龄和早产。
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8
Correlation of cell-free DNA plasma concentration with severity of non-alcoholic fatty liver disease.游离DNA血浆浓度与非酒精性脂肪性肝病严重程度的相关性。
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Comparative evaluation of the Minimally-Invasive Karyotyping (MINK) algorithm for non-invasive prenatal testing.用于无创产前检测的微创核型分析（MINK）算法的比较评估
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10
Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.丁酸盐和 Wnt-5a 的生物活性蛋白水解形式调节结肠上皮细胞的增殖和空间发育。
Sci Rep. 2016 Aug 26;6:32094. doi: 10.1038/srep32094.

新生儿坏死性小肠结肠炎相关的 DNA 甲基化特征在受累个体的粪便样本中是明显的。

Neonatal necrotizing enterocolitis-associated DNA methylation signatures in the colon are evident in stool samples of affected individuals.

机构信息

Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Departments of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA.

出版信息

Epigenomics. 2021 Jun;13(11):829-844. doi: 10.2217/epi-2021-0078. Epub 2021 Apr 27.

DOI:10.2217/epi-2021-0078
PMID:33905263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8293031/
Abstract

Neonatal necrotizing enterocolitis (NEC) is a deadly and unpredictable gastrointestinal disease, for which no biomarker exists. We aimed to describe the methylation patterns in stool and colon from infants with NEC. We performed a high-resolution genome-wide epigenomic analysis using solution-phase hybridization and next-generation sequencing of bisulfite-converted DNA. Our data reveal significant genomic hypermethylation in NEC tissues compared with non-NEC controls. These changes were more pronounced in regions outside CpG islands and gene regulatory elements, suggesting that NEC-specific hypermethylation is not a nonspecific global phenomenon. This study provides evidence of a methylomic signature associated with NEC that is detectable noninvasively and provides a new opportunity for the development of a novel diagnostic method for NEC.

摘要

新生儿坏死性小肠结肠炎（NEC）是一种致命且难以预测的胃肠道疾病，目前尚无生物标志物。我们旨在描述患有 NEC 的婴儿粪便和结肠中的甲基化模式。我们使用溶液相杂交和亚硫酸氢盐转化 DNA 的下一代测序进行了高分辨率全基因组表观基因组分析。与非 NEC 对照相比，我们的数据显示 NEC 组织中存在显着的基因组高甲基化。这些变化在 CpG 岛和基因调控元件之外的区域更为明显，这表明 NEC 特异性高甲基化不是非特异性的全局现象。这项研究提供了与 NEC 相关的甲基组特征的证据，该特征可通过非侵入性检测到，并为开发 NEC 的新型诊断方法提供了新的机会。