RTI International, Research Triangle Park, North Carolina.
LunaPBC, San Diego, California.
Curr Protoc. 2021 Apr;1(4):e111. doi: 10.1002/cpz1.111.
The PhenX (consensus measures for Phenotypes and eXposures) Toolkit (https://www.phenxtoolkit.org/) is a publicly available, web-based catalog of recommended, well-established measurement protocols of phenotypes and exposures. The goal of PhenX is to facilitate the use of standard measures, enhance data interoperability, and promote collaborative and translational research. PhenX is driven by the scientific community and historically has depended on working groups of experts to recommend measures for release in the PhenX Toolkit. The urgent need for recommended, standard measures for COVID-19 research triggered the development of a "rapid release" process for releasing new content in the PhenX Toolkit. Initially, PhenX collaborated with the National Institutes of Health (NIH) Office of Behavioral and Social Sciences Research, the National Human Genome Research Institute, and the NIH Disaster Research Response (DR2) program to create a library of COVID-19 measurement protocols. With additional support from NIH, PhenX adapted crowdsourcing techniques to accelerate prioritization and recommendation of protocols for release in the PhenX Toolkit. Prioritized COVID-19-specific protocols were used to anchor and define specialty collections of protocols that were subject to review and approval by the PhenX Steering Committee. In addition to the COVID-19-specific protocols, the specialty collections include existing, well-established PhenX protocols, use of which will further enhance data interoperability and cross-study analysis. The COVID-19 specialty collections are Behaviors and Risks; Ethnicity, Race and Demographics; History, Treatment and Outcomes; Information Resources; Psychosocial and Mental Health; and Socioeconomic. The development and usage of PhenX COVID-19 specialty collections are described in this article. © 2021 The Authors. Basic Protocol: Selecting COVID-19 protocols.
PhenX（表型和暴露共识测量工具包）（https://www.phenxtoolkit.org/）是一个公开的、基于网络的推荐、成熟的表型和暴露测量协议目录。 PhenX 的目标是促进使用标准测量方法、增强数据互操作性，并促进合作和转化研究。 PhenX 由科学界推动，历史上一直依赖专家组推荐措施，以在 PhenX 工具包中发布。对 COVID-19 研究推荐、标准措施的迫切需求促使 PhenX 为在 PhenX 工具包中发布新内容开发了“快速发布”流程。最初，PhenX 与美国国立卫生研究院（NIH）行为和社会科学研究办公室、国家人类基因组研究所和 NIH 灾难研究响应（DR2）计划合作，创建了一个 COVID-19 测量协议库。在 NIH 的额外支持下，PhenX 采用众包技术加速协议的优先级排序和推荐，以在 PhenX 工具包中发布。优先考虑 COVID-19 特定的协议，用于锚定和定义专门的协议集合，这些协议集合需要经过 PhenX 指导委员会的审查和批准。除了 COVID-19 特定的协议外，专门的协议集合还包括现有的、成熟的 PhenX 协议，使用这些协议将进一步增强数据互操作性和跨研究分析。 COVID-19 专业协议集合包括行为和风险、族裔、种族和人口统计学、历史、治疗和结果、信息资源、心理社会和心理健康以及社会经济。本文描述了 PhenX COVID-19 专业协议集合的开发和使用。 © 2021 作者。基本方案：选择 COVID-19 协议。
