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使用PhenX工具包为研究添加标准测量方法。

Using the PhenX Toolkit to Add Standard Measures to a Study.

作者信息

Hendershot Tabitha, Pan Huaqin, Haines Jonathan, Harlan William R, Marazita Mary L, McCarty Catherine A, Ramos Erin M, Hamilton Carol M

机构信息

RTI International, Research Triangle Park, North Carolina.

Case Western Reserve University, Cleveland, Ohio.

出版信息

Curr Protoc Hum Genet. 2015 Jul 1;86:1.21.1-1.21.17. doi: 10.1002/0471142905.hg0121s86.

DOI:10.1002/0471142905.hg0121s86
PMID:26132000
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8029591/
Abstract

The PhenX (consensus measures for Phenotypes and eXposures) Toolkit (https://www.phenxtoolkit.org/) offers high-quality, well-established measures of phenotypes and exposures for use by the scientific community. The goal is to promote the use of standard measures, enhance data interoperability, and help investigators identify opportunities for collaborative and translational research. The Toolkit contains 395 measures drawn from 22 research domains (fields of research), along with additional collections of measures for Substance Abuse and Addiction (SAA) research, Mental Health Research (MHR), and Tobacco Regulatory Research (TRR). Additional measures for TRR that are expected to be released in 2015 include Obesity, Eating Disorders, and Sickle Cell Disease. Measures are selected by working groups of domain experts using a consensus process that includes input from the scientific community. The Toolkit provides a description of each PhenX measure, the rationale for including it in the Toolkit, protocol(s) for collecting the measure, and supporting documentation. Users can browse measures in the Toolkit or can search the Toolkit using the Smart Query Tool or a full text search. PhenX Toolkit users select measures of interest to add to their Toolkit. Registered Toolkit users can save their Toolkit and return to it later to revise or complete. They then have options to download a customized Data Collection Worksheet that specifies the data to be collected, and a Data Dictionary that describes each variable included in the Data Collection Worksheet. The Toolkit also has a Register Your Study feature that facilitates cross-study collaboration by allowing users to find other investigators using the same PhenX measures.

摘要

PhenX（表型和暴露的共识测量）工具包（https://www.phenxtoolkit.org/）为科学界提供高质量、成熟的表型和暴露测量方法。其目标是促进标准测量方法的使用，增强数据的互操作性，并帮助研究人员识别合作研究和转化研究的机会。该工具包包含从22个研究领域（研究方向）选取的395项测量方法，以及针对药物滥用与成瘾（SAA）研究、心理健康研究（MHR）和烟草监管研究（TRR）的额外测量方法集合。预计2015年发布的TRR的其他测量方法包括肥胖、饮食失调和镰状细胞病。测量方法由领域专家工作组通过共识流程选定，该流程包括来自科学界的意见。该工具包提供了每项PhenX测量方法的描述、将其纳入工具包的理由、收集该测量方法的方案以及支持文档。用户可以浏览工具包中的测量方法，也可以使用智能查询工具或全文搜索来搜索工具包。PhenX工具包用户选择感兴趣的测量方法添加到他们的工具包中。注册的工具包用户可以保存他们的工具包，之后再返回进行修订或完善。然后他们可以选择下载定制的数据收集工作表，该工作表指定了要收集的数据，以及一个数据字典，该字典描述了数据收集工作表中包含的每个变量。该工具包还有一个“注册你的研究”功能，通过允许用户找到使用相同PhenX测量方法的其他研究人员，促进跨研究合作。

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