Programa de Pós-Graduação em Endocrinologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil,
Arch Endocrinol Metab. 2021 Nov 1;65(2):164-171. doi: 10.20945/2359-3997000000332. Epub 2021 Feb 24.
The aim of this study was to evaluate the frequency of hypoglycemia and the treatment satisfaction in patients with type 1 diabetes (T1D) using insulin analogues.
This observational retrospective study included 516 adult patients with T1D from 38 cities in Southern Brazil. Demographics and clinical data were collected using a self-report questionnaire. Hypoglycemia was defined as an event based on either symptoms or self-monitored blood glucose < 70 mg/dL. Treatment satisfaction was evaluated using the Diabetes Treatment Satisfaction Questionnaire status version (DTSQs) and with a specific question with scores ranging from 0-10. Common mental disorders were assessed using the General Health Questionnaire (GHQ-12).
Overall, the mean age was 38 ± 14 years and 52% of the participants were women. The median diabetes duration was 18 years. The scores for insulin analogue treatment satisfaction were higher than those for previous treatments. DTSQ scores had a median value of 32 (interquartile range 29-35) and remained unchanged over time. The percentage of patients with hypoglycemia (including severe and nocturnal) was comparable across groups divided according to duration of use of insulin analogues. Most patients (n=395, 77%) screened positive for common mental disorders.
Patient satisfaction with insulin analogue treatment was high and remained unchanged with time. Episodes of hypoglycemia also remained unchanged over time among patients using insulin analogues.
本研究旨在评估使用胰岛素类似物的 1 型糖尿病（T1D）患者低血糖的发生频率和治疗满意度。
这是一项观察性回顾性研究，纳入了来自巴西南部 38 个城市的 516 名成年 T1D 患者。使用自我报告问卷收集人口统计学和临床数据。低血糖的定义为基于症状或自我监测的血糖<70mg/dL 的事件。使用糖尿病治疗满意度问卷状态版本（DTSQs）和 0-10 分的特定问题评估治疗满意度。使用一般健康问卷（GHQ-12）评估常见精神障碍。
总体而言，患者的平均年龄为 38±14 岁，其中 52%为女性。糖尿病病程中位数为 18 年。胰岛素类似物治疗满意度评分高于以往治疗。DTSQ 评分的中位数为 32（四分位距 29-35），且随时间保持不变。根据胰岛素类似物使用时间长短分组，低血糖（包括严重和夜间）的患者比例相似。大多数患者（n=395，77%）筛查出常见精神障碍。
患者对胰岛素类似物治疗的满意度较高，且随时间保持不变。使用胰岛素类似物的患者中，低血糖的发作也随时间保持不变。
