一位肺腺癌患者出现的纳武单抗诱发的多肌痛性风湿症。
Nivolumab-Induced Polymyalgia Rheumatica in a Patient with Lung Adenocarcinoma.
作者信息
Kita Toshiyuki, Araya Tomoyuki, Sakai Tamami, Uchida Yuka, Matsuoka Hiroki, Kasahara Kazuo
机构信息
Department of Respiratory Medicine, National Hospital Organization Kanazawa Medical Center, Kanazawa, Ishikawa, Japan.
Department of Respiratory Medicine, National Hospital Organization Kanazawa Medical Center, Kanazawa, Ishikawa, Japan.
出版信息
Am J Med Sci. 2021 Sep;362(3):321-323. doi: 10.1016/j.amjms.2021.04.010. Epub 2021 Apr 24.
A 79-year-old woman was diagnosed with stage IV (cT1aN1M1, OSS) lung adenocarcinoma with bone metastasis of the right femur. She received nivolumab as a third-line treatment. She developed pain in the right shoulder, left wrist, right knee, and waist as well as a low-grade fever and morning stiffness, after five courses of nivolumab. After closer examination, she was diagnosed with polymyalgia rheumatica (PMR) precipitated by an immune-related adverse event. Nivolumab was discontinued, and oral prednisolone was started. Her arthralgia improved. Caution should be exercised regarding the development of PMR when polyarthralgia occurs during nivolumab treatment in patients with lung cancer.
一名79岁女性被诊断为IV期（cT1aN1M1，OSS）肺腺癌伴右股骨骨转移。她接受纳武单抗作为三线治疗。在接受五个疗程的纳武单抗治疗后，她出现了右肩、左手腕、右膝和腰部疼痛，以及低热和晨僵。经过仔细检查，她被诊断为由免疫相关不良事件诱发的风湿性多肌痛（PMR）。停用纳武单抗，并开始口服泼尼松龙。她的关节痛有所改善。肺癌患者在接受纳武单抗治疗期间出现多关节痛时，应注意PMR的发生。
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