Nakao Makoto, Hirano Ayami, Nakai Masato, Hayashi Syuntaro, Kuriyama Mamiko, Takeda Norihisa, Muramatsu Hideki
Department of Respiratory Medicine, Kainan Hospital Aichi Prefectural Welfare Federation of Agricultural Cooperatives, Yatomi, Aichi 498-8502, Japan.
Exp Ther Med. 2025 Apr 2;29(6):109. doi: 10.3892/etm.2025.12859. eCollection 2025 Jun.
A 54-year-old man was referred to Kainan hospital (Yatomi, Japan) in June 2014 with a chief complaint of right hip pain. Computed tomography showed a pelvic tumor and a nodule in the right upper lobe of the lung. After transbronchial lung tumor biopsy and full-body screening, the patient was diagnosed with stage IV lung cancer. Epidermal growth factor receptor mutation and anaplastic lymphoma kinase fusion gene were not detected, and programmed cell death ligand 1 was negative. From July 2014, while undergoing radiotherapy to the right pelvic region, the patient also received combination therapy with carboplatin, paclitaxel and bevacizumab. The patient subsequently received pemetrexed monotherapy and docetaxel monotherapy, as well as radiotherapy, for right adrenal metastasis. From February 2019, the patient was administered nivolumab, which was effective, but 3 years and 3 months after the start of nivolumab treatment, he developed diabetes mellitus and insulin therapy was started. Then, 4 years and 5 months after the start of nivolumab, the patient developed polymyalgia rheumatica and was treated with prednisolone. The present study reports a rare case of diabetes mellitus and polymyalgia rheumatica in a patient with lung cancer who had received nivolumab treatment for more than 4 years.
一名54岁男性于2014年6月因右髋部疼痛为主诉被转诊至日本八户市海南医院。计算机断层扫描显示盆腔有肿瘤，右肺上叶有结节。经支气管肺肿瘤活检及全身检查后，该患者被诊断为IV期肺癌。未检测到表皮生长因子受体突变和间变性淋巴瘤激酶融合基因，程序性细胞死亡配体1为阴性。自2014年7月起，在对右盆腔区域进行放射治疗的同时，患者还接受了卡铂、紫杉醇和贝伐单抗的联合治疗。随后，患者接受培美曲塞单药治疗和多西他赛单药治疗，以及针对右肾上腺转移的放射治疗。自2019年2月起，患者接受纳武单抗治疗，治疗有效，但在纳武单抗治疗开始3年零3个月后，他患上了糖尿病并开始胰岛素治疗。然后，在纳武单抗治疗开始4年零5个月后，患者患上了风湿性多肌痛，并接受了泼尼松龙治疗。本研究报告了一例接受纳武单抗治疗超过4年的肺癌患者发生糖尿病和风湿性多肌痛的罕见病例。
