Krivoĭ I I
Biull Eksp Biol Med. 1988 Jun;105(6):665-7.
Miniature end-plate currents (MEPC) were recorded in voltage clamped muscle fibers of the rat diaphragm at different degrees of acetylcholinesterase (AChE) inhibition with galanthamine. A model has been suggested connecting the increase in MEPC amplitude with the concentration of a competitive reversible AChE inhibitor. Using the model suggested, the changes in the junctional AChE activity inhibited with different concentrations of galanthamine were estimated. The calculated value of the inhibitory galanthamine constant is 2.8 X 10(-7) M.
在不同程度的加兰他敏抑制乙酰胆碱酯酶（AChE）的情况下，记录大鼠膈肌电压钳制肌纤维中的微小终板电流（MEPC）。有人提出了一个模型，将MEPC幅度的增加与竞争性可逆AChE抑制剂的浓度联系起来。利用所提出的模型，估计了不同浓度加兰他敏抑制的接头处AChE活性的变化。加兰他敏抑制常数的计算值为2.8×10⁻⁷ M。
