[移植物抗宿主反应中甲状腺腺细胞发生肿瘤转化的可能性]
[Possibility of the neoplastic transformation of thyroid gland cells in the graft vs host reaction].
作者信息
Kozlova T D, Zarudin V V, Kozlov N B
出版信息
Biull Eksp Biol Med. 1988 Jun;105(6):713-5.
The experiments were carried out on 60 first generation hybrids. Acute systemic "graft-versus-host" reaction (GVHR) was induced in (CBA X C57B1/6) X 60 X 10(6) hybrids by intravenous administration of spleen cells from C57B1/6 parents. Thyroid glands were examined on the 3rd, 10th and 24th days of GVHR. Chronic GVHR was studied in accordance with routine model. (C57B1/6 X DBA/2) hybrids were given 50 X 10(6) spleen cells from DBA/2 parents. Thyroid glands were investigated 6 months after GVHR induction. On the 10th day of GVHR histological examination revealed that follicular-like adenoma tumours with pronounced cellular abnormalities tended to appear in thyroid gland. In a chronic form of GVHR the histological pattern corresponds to that of follicular cancer.
实验在60只第一代杂种动物身上进行。通过静脉注射C57B1/6亲代的脾细胞，在（CBA×C57B1/6）×60×10⁶杂种动物中诱导急性全身性“移植物抗宿主”反应（GVHR）。在GVHR的第3天、第10天和第24天检查甲状腺。按照常规模型研究慢性GVHR。给（C57B1/6×DBA/2）杂种动物注射50×10⁶个来自DBA/2亲代的脾细胞。在GVHR诱导6个月后研究甲状腺。在GVHR的第10天，组织学检查显示甲状腺中倾向于出现具有明显细胞异常的滤泡样腺瘤肿瘤。在慢性GVHR形式中，组织学模式与滤泡癌的模式相符。
Zotero 插件