COVID-19 患者记忆 T 细胞的功能反应性。
Functional responsiveness of memory T cells from COVID-19 patients.
机构信息
Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
Department of Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
出版信息
Cell Immunol. 2021 Jul;365:104363. doi: 10.1016/j.cellimm.2021.104363. Epub 2021 Apr 17.
The presence of memory T cells in COVID-19 patients has been acknowledged, however the functional potency of memory responses is critical for protection. In this study, naïve, effector, effector memory, and central memory CD4 and CD8 T cells obtained from the COVID-19 survivors were re-exposed to autologous monocyte-derived DCs that were loaded with SARS-CoV-2 spike glycoprotein S1. Proliferation capacity, CD25, 4-1BB, and PD-1 expression, and IFN-γ, IL-6, granzyme, granulysin, and FasL secretion were enhanced in CD4 and CD8 effector memory and central memory T cells. Albeit being at heterogeneous levels, the memory T cells from the individuals with COVID-19 history possess functional capacities to reinvigorate anti-viral immunity against SARS-CoV-2.
在 COVID-19 患者中已经发现了记忆 T 细胞的存在，然而记忆应答的功能效力对于保护至关重要。在这项研究中，从 COVID-19 幸存者中获得的幼稚、效应、效应记忆和中央记忆 CD4 和 CD8 T 细胞重新暴露于自体单核细胞衍生的树突状细胞，这些细胞负载了 SARS-CoV-2 刺突糖蛋白 S1。在 CD4 和 CD8 效应记忆和中央记忆 T 细胞中，增殖能力、CD25、4-1BB 和 PD-1 表达以及 IFN-γ、IL-6、颗粒酶、颗粒溶素和 FasL 的分泌增强。尽管存在异质性水平，但具有 COVID-19 病史的记忆 T 细胞具有重新激活针对 SARS-CoV-2 的抗病毒免疫的功能能力。
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